The Diagnosis And Treatment Of 56 Cases With Primary Biliary Cirrhosis

Objective:Clinical feature of primary biliary cirrhosis(PBC) were reviewed in order to improve its diagnosis in our clinical practice.Methods:The clinical date of 56 patients with PBC were reviewed including the clinical manifestation, laboratory tests pathological findings and response to therapy.Results:Patients were female 94.6%. The most frequently symptoms were fatigue 82.1%, anorexia 80.4%, and pruritus 66.1%, the major signs included jaundice 64.3%, splenomegaly 59.2%. Serum alkaline phosphatase(ALP) and gamma-glutamyl transpetidase (γ-GT) levels were markedly elevated in majority patients. The serum TBIL and DBIL level increased in patients.25patients(44.6)% had elevated serum IgM, and (89.3)% of patients were anti-mitochondrial antibody (AMA)/AMA-M2 positive.34 cases of PBC patients treated by ursodeoxycholic acid, and trere are no statistical significance between the clinical and the liver fuction before and after the treatment.Conclusion:PBC most frequently occurs in middle-aged women and the main clinical manifestations are weak、anorexia、pruritus and jaundice. Elevated serum ALP、γ-GT levels together with positive AMA/AMA-M2 can help to diagnosis. Treatment with UDCA as the main comprehensive treatment can significantly improve the clinical manifestations of PBC patients.