The Effect Of Uterine Artery Interventional Chemoembolization In The Treatment Of Middle And Lat Cervical Cancer

Object:A retrospective analysis of our hospital since uterine artery interventional chemoembolization applied in the mid and late cervical cancers achieved.Methods:On January 2006 to September 2014 in yanbian hospital inpatient treatment of 126 cases of advanced cervical carcinoma and clinical stage IB2 and above stage, tumor is more than or equal to 4 cm with varying degrees of activity of vaginal bleeding, no other important organs serious diseases and infectious diseases of 98 patients underwent Uterine artery interventional chemoembolization. We combined with clinical practice choice chemotherapy DDP (cisplatin) 40mg+BLM (BLM) 15mg+5-FU (fluorouracil) 0.5mg. Before treatment by physical, examination and auxiliary examination records of tumor size, and record the amount of vaginal bleeding. After interventional therapy on vaginal ram gauze (gauze specifications 40 x 40cm, the blood volume was 50ml) is 6 hours,24 hours and 72 hours to replace the gauze was the amount of bleeding. All of the patients after 3 weeks by physical examination and auxiliary examination records after the treatment of the lesion size, size comparison before and after the mass change. The adverse reactions of chemotherapy drugs after interventional chemotherapy for uterine artery interventional chemoembolization adverse reactions were observed. After treatment, the follow-up of the treatment, tumor residual and lymphatic metastasis, follow-up of long-term efficacy and 5 year survival rate were followed.Result:55 cases with vaginal bleeding of patients with cervical cancer underwent uterine artery interventional chemoembolization for 6 hours after effective control of hemorrhage of 20 cases; after 24 hours and effective control of hemorrhage for 48 cases. The remaining 7 cases 72 hours after the turn for bloody secretions, all to achieve effective control of hemorrhage; within 24 hours of vaginal bleeding effective control rate was 100.0%in the period of IB2, â…¡al 100.0%, the stage of â…¡a286.7%, â…¡b 83.3%, â…¢ period 70.0%. The effective control rate of the patients with middle and advanced cervical cancer with the large bleeding of vagina was 100% in 72 hours.98 cases of patients completed a course of treatment of Uterine artery interventional chemoembolization, after 3 weeks observation indexes,18 cases (18.4%) tumors disappeared; 60 cases of mass volume decreased more than 50%; Uterine artery interventional chemoembolization in the total efficiency of 79.6% (78/98). There are some adverse reactions such as the inhibition of the marrow, nausea and vomiting, anemia, medicine fever, liver function and so on in the course of the treatment. Nausea and vomiting were the most common, and were relieved after symptomatic treatment.3 weeks after the assessment of efficacy, the â… b2 to â…¡a2 stage 48 patients with the physical conditions and tolerance surgery patients underwent cervical cancer radical resection; â…¡b to â…¢ patients with direct radiotherapy. The postoperative pathological report:histological examination no residual carcinoma in 17 cases, is a pathological complete remission in radical resection of cervical cancer,7 cases with parametrial infiltration lesions and 9 cases of pelvic lymph node metastasis,2 cases of vaginal cut margin positive,8 cases of vascular found tumor thrombus, which also have parametrial infiltration lesions and lymph node metastatic lesions in 5 cases. The rate of lymph node metastasis was 29.2%(14/48) after uterine artery interventional chemoembolization in this data. Of the 98 cases of cervical cancer treated with uterine artery interventional chemoembolization, only 59 cases were followed up, the survival rates of 1,3 and 5 were 98.3%,84.7% and 71.2%.Conclusion:Uterine artery interventional chemoembolization of cervical lesions was significantly reduced, active bleeding achieve hemostasis; short time rapidly relieve clinical symptoms, improve operation rate and tumor cut net rate, for later treatment to provide favorable conditions; a certain degree of delay time of tumor recurrence or metastasis, so as to improve the short-term quality of life. Uterine artery interventional chemoembolization on mid and late cervical cancers short-term curative effect can not be ignored, but the long-term efficacy and improve 5 year survival rate is no obvious effect.