Controllable Synthesis, Photothermal Performance And Application Of Multielemental Copper-based Semiconductors

This thesis was committed to study preparation, characterization and photothermal properties of copper-based photothermal agents. The main research work is listed as the following parts:(1) PEGylated Cu3 Bi S3 hollow nanospheres(HNSs) have been synthesized through a facile solvothermal route at 200 oC for 1 h, employing Bi(NO3)3?5H2O, Cu Cl2 and PEG(Mn = 2000) as reaction reagents. The as-obtained products were characterized by X-ray diffraction(XRD), Field-emission scanning electron microscope(FE-SEM), Transmission electron microscope(TEM), BET specific surface area, X-ray photoelectron spectroscopy(XPS), energy dispersion X-ray(EDX), UV-vis absorbance spectra, UV-vis diffuse reflectance spectroscopy, Fourier-transform infrared(FT-IR) spectra in detail. The photothermal properties of PEGylated Cu3 Bi S3 HNSs under irradiation of NIR light were investigated through series of photothermal experiments. The results on basis of calculations showed that 27.5% of photothermal transduction efficiency could be achieved over Cu3 Bi S3 HNSs. The Cu3 Bi S3 HNSs also showed good antitumoral drug doxorubicin(DOX) loading capacity and p H- and NIR-responsive DOX release behaviors. At a low dosage of 10 ppm, He La cells could be efficiently killed through a synergistic effect of chemo- and photothermo-therapy respectively based on the DOX release and the photothermal effect of Cu3 Bi S3 HNSs. Furthermore, Cu3 Bi S3 HNSs displayed good X-ray computed tomography(CT) imaging capability, which can be used as imaging-guided cancer therapy in the future. This multifunctional theranostic nanomaterial shows a potential promise for cancer therapy.(2) Cu2(OH)PO4 microcrystals with six different morphologies were respectively synthesized through a wet chemical route, employing Cu(CH3COO)2.H2 O or Cu(NO3)2 and(NH4)2HPO4 as chemical reagents. The as-obtained products were characterized by XRD, FE-SEM, UV-vis DRS, TG, FT-IR in detail. Under 808 nm laser irradiation, morphology-dependent photothermal performance of Cu2(OH)PO4 was systematically studied. The experimental results showed that the photothermal effect of Cu2(OH)PO4 of rod-like structure was superior to other three morphologies. Combined with photoenergy absorption ability, the lattice vibration, the phonon transmission direction and grain shape of the material, the mechanism of photothermal performance differences among Cu2(OH)PO4 microcrystals was discussed. The present research provides valuable reference for the design of the high-efficiency photothermal materials.