The Influence Of The UGT1A1*28 Polymorphism And TCM Syndrome Type On The Adverse Reactions Of Irinotecan

Objective: To further inquiry the influence of the UGT1A1*28 Polymorphism and TCM syndrome type on the adverse reactions of irinotecan.Methods: Statistical analysis the UGT1A1*28 genotypes of 93 cases of colon cancer patients.And for syndrome differentiation of traditional Chinese medicine on patients. Observation and analysis the influence of the UGT1A1*28 Polymorphism and TCM syndrome type on the adverse reactions of irinotecan.All data were analyzed with SPSS19 software.Results:1.The distribution of the UGT1A1*28 Polymorphism:42 cases of colon cancer patients were collected,65 cases(69.9%) were the wild genotype TA6/6,26 cases(27.9%) were heterozygous TA6/7,2 cases(2.2%) were the wild genotype TA7/7.2.The occurrence of adverse reactions:31 of 91 cases(34.1%) were found delayed diarrhea,17 cases(18.7%) degree I-II and 14 cases(15.4%) degree III-IV;Neutropenia occurs in 21 cases(23.1%),13 cases(14.3%) degree I-II and 8 cases(8.8%) degree III-IV.3.The relationship between UGT1A1*28 genotypes and adverse reactions:The incidence rate of overall delayed diarrhea in patients with genotype TA6/6 was lower than that in patients with heterozygous TA6/7(50.0% vs 27.7%,P=0.043) and no significant difference in the incidence rate of III-IV neutropenia(19.2% vs 13.8%,P =0.520).There was no significant difference in the incidence rate of delayed diarrhea(P>0.05).4.TCM syndrome type of colorectal cancer:(1)Stasis poison accumulate knot,(2)damp-heat syndrome large intestine,(3)spleen deficiencysyndrome,(4)deficiency of both qi and blood,(5) liver and kidney yin deficiency syndrome.5.The Relationship between TCM syndrome type and Adverse reactions:Spleen deficiencysyndrome patients than other type after using the set for kang in patients are more likely to have diarrhea and grade III-IV late-onset diarrhea(P<0.05).Positive patients are more likely to happen neutropenia and grade III-IV neutropenia(P<0.05).Conclusion:1.In the UGT1A1*28 genotypes TA6/7 less TA6/6 patients are more likely to have diarrhea.But not found with the level III-IV late-onset diarrhea have obvious correlation. Didn’t find UGT1A1*28 genotypes neutropenia have obvious correlation.2.Spleen deficiencysyndrome patients are more likely to have diarrhea and grade III-IV late-onset diarrhea than other type.Positive patients are more likely to happen neutropenia and grade III-IV neutropenia.