CRP, PCT In Assessing The Severity Of Acute Pancreatitis And Prognosis Of Clinical Value Analysis

Objectives Dynamic observation of acute pancreatitis during the first week of serum Creactive protein, procalcitonin changes. By analyzing research data changes of C-reactive protein, procalcitonin in the estimated severity of acute pancreatitis and its clinical significance prognosis.Methods The February 2013 to December 2014 admission diagnosis of acute pancreatitis observational study included 82 patients. Extracting the patient venous in1,3,5,7 day with CRP, PCT concentrations measured, and make blood tests CT,APACHE-â…¡ score for all patients. According to the severity of the AP, and whether the occurrence of organ failure, secondary infection has occurred, whether the occurrence of pancreatic necrosis patients were divided into two groups. Comparison between the two groups CRP, PCT difference of statistical methods using independent sample t test, when P <0.05 the difference was statistically significant. Predicting AP severity and prognostic factors were analyzed using receiver operating curve, calculation CRP, PCT, APACHEâ…¡score area under the ROC curve, the area under the curve is 1, predictive diagnostic value to compare CRP, PCT, APACHE-â…¡ comparison by the area under the curve.Results Between patients with acute pancreatitis in mild group and severe group,difference of CRP, PCT be provided with statistically significant in 1,3,5,7 days(P<0.05). Day 7 CRP, day 5 PCT, and admission APACHE-â…¡ score in the ROC curves successively were 0.859,0.906,0.984. Between organ failure group and non organ failure group, CRP was no significant difference on day 1(P >0.05), difference of CRP be provided with statistically significant in 3,5,7 days(P <0.05), PCT was no significant difference on day 1(P >0.05), difference of PCT be provided with statistically significant in 3,5,7 days(P <0.05),Day 7 CRP, day 7 PCT, and admission APACHE-â…¡ score in the ROC curves successively were0.849,0.881,0.971. Between secondary infection group and non secondary infection group, CRP was no significant difference in 1,3days(P >0.05),difference of CRP be provided with statistically significant in 5,7 days(P<0.05), PCT was no significant difference on day 1(P >0.05), difference of PCT be provided with statistically significant in 3,5,7 days(P <0.05), Day 5 CRP, day 7 PCT, and admission APACHE-â…¡ score in the ROC curves successively were 0.743,0.820,0.944. Between pancreatic necrosis group and non pancreatic necrosis group, difference of CRP, PCT be provided with statistically significant in 1,3,5,7 days(P <0.05), Day 7 CRP, day 5 PCT,and admission APACHE-â…¡score in the ROC curves successively were0.846,0.919,0.961.Conclusions CRP, PCT measurement has important clinical significance in predicting the severity of acute pancreatitis and prognostic factors that can predict earlier associated complications.In CRP, PCT, APACHE-â…¡ score of ROC curve analysis, APACHE-â…¡score accuracy better than PCT, PCT better than CRP. In assessing the severity of acute pancreatitis and pancreatic necrosis aspect, CRP, PCT has high accuracy, In terms of secondary infection and organ failure assessment, CRP, PCT accuracy is relatively poor compared with the previous two.