| Objective: To detect the serum levels of p53 protein and soluble Fas(s Fas) protein in Han Nationality patients with gastric cancer(GC), chronic atrophic gastritis(CAG) and chronic superficial gastritis(CSG) in Qinghai area and to discuss their significance for diagnosing the GC.Methods: 31 GC patients,28 CAG patients and 30 CSG patients of Han Nationality with GC,were collected from November 2013 to October 2014 in the Affiliated Hospital of Qinghai University. The levels of serum p53 protein and s Fas were detected using enzyme-linked immunosorbent assay(ELISA). The difference of serum p53 and s Fas levels among three groups and the correlation of p53 and s Fas were analyzed.Results: 1.The levels of p53 protein in GC,CAG and CSG were(34.60 ±3.73)g/m L,(28.66±5.13) g/m L and(23.33±3.94) g/m L,there was significant difference in p53 protein levels(P<0.05).Serum p53 protein levels in GC group increased significantly than in CAG group and CSG group(P<0.05).Serum p53 protein levels in CAG group increased significantly than in CSG group(P<0.05).2.The levels of s Fas protein in GC,CAG and CSG were(1259.56±111.08)ng/L,(1324.32±102.95)ng/L and(1373.86±145.64)ng/L.The level of serum s Fas in GC group was significantly lower than CAG group and CSG group(P<0.05).3.The serum p53 protein was negatively correlated with s Fas in GC group,r=-0.543, P<0.05.Conclusions:1. The level of serum p53 protein increased in CSG group compare to CAG group, and to GC group, in turn. suggesting that p53 protein level elevates along with the progression of disease. 2.The level of s Fas in serum in GC group is significantly lower than that of CAG group and CSG group,prompt s Fas level in serum may be as an important reference index of diagnosis of GC.3.The serum p53 is negatively correlated with s Fas protein in the GC group. These results indicate that the joint detection of p53 and s Fas may provide certain reference significance for the diagnosis of GC. |
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