| Objective To investigate the relationship of serum C1q/TNF-related protein 5(CTRP5) with coronary artery restenosis after drug-eluting stent(DES) based percutaneous coronary intervention(PCI).Methods Clinical characteristics, biochemical measurements, medical treatments, left ventricular ejection fraction(LVEF), serum CTRP5 and coronary interventional features were assessed in 258 consecutive patients with angiographic ISR and 260 age- and sex-matched patients without ISR at one-year after PCI with sirolimus-eluting stent implantation. Multivariate Logistic regression analysis was performed to determine the independent factors for ISR.Results Compared with non-ISR patients, those with ISR had higher incidence of prior myocardial infarction and were more likely to be diabetic and cigarette smokers. Serum levels of low-density lipoprotein cholesterol(LDL-C),apoliprotein B, high-sensitivity C-reactive protein, and glycosylated hemoglobin were higher, but LVEF was lower in patients with ISR. Despite similar degree of coronary disease and site of stent implantation, stent diameter was smaller, stent length was longer, and bifurcation stenting was more common in patients with ISR. The level of CTRP5 in ISR group was significantly higher than that in the control group(P < 0.05).Multivariate Logistic regression analysis revealed that prior myocardial infarction, diabetes, cigarette smoking, elevated hs-CRP, LDL-C, and CTRP5, and greater stent length were independent risk factors for ISR, whereas stent diameter and LVEF were inversely associated with ISR.Conclusion ISR after sirolimus-eluting stent implantation was related to multiple clinical and coronary angiographic and interventional factors. Elevated serum CTRP5 level is an independent predictor for ISR. Optimal control of traditional risk factors and improvement of left ventricular function were crucial in reducing ISR, particularly for patients with small vessel disease, long lesion(stents) and bifurcation stenting. |
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