Colorectal Cancer And Colorectal Polyps Follow-up Case Control Study

Objective: Collecting cases of colorectal polyp patients and colorectal cancer patients, who visited to the Shaanxi province people’s hospital ofgastroenterological department nearly ten years. To explore the major risk factors of colorectal polyp progress to colorectal cancer and provide a scientific basis for early detection of colorectal cancer to improve the prognosis and quality of life.Methods:259 cases of colorectal cancer and 287 cases of colorectal polyps were detected by colonoscopy in cavity mirror center of Shaanxi province people’s hospital from 2000 to 2013. Patient characteristics(age and gender, etc.),clinical manifestations,dietary factor, family history and past medical history were classified and analyzed systematically..Results: 1. The differences of gender distribution in colorectal cancer group and colorectal polyps group are not statistically significant(P>0.05).2.The number of young patients(<40 years old) in colorectal cancer group are higher than those in colorectal polyps group, and the differences are statistically significant(P<0.05). And the middle-aged patients(40~60 years old) in colorectal cancer group are less than those in colorectal polyps group, and the differences are statistically significant(P<0.01). Compared with colorectal polyps group, there are more aged patients in colorectal cancer group, and the differences are statistically significant(P<0.01).3.There are significant differences between colorectal cancer group and colorectal polyps group in main clinical manifestations, such as diarrhea(P<0.01), fecal occult blood(P<0.05), hematochezia(P<0.01),abdominal pain(P<0.05).4.Compared with colorectal polyps group, there are the great majority of patients in colorectal cancer group have gallstone or cholecystotomy aspast medical history, and the differences are statistically significant(P<0.05). Compared with colorectal polyps group, there are the great majority of patients in colorectal cancer group have appendicitisor Appendectomy as past medical history, and the differences are statistically significant(P<0.01).5.Colorectal cancer patients with colorectal polyps group compared with patients like eating fatty food accounts for a relatively large proportion,and the differences are statistically significant(P<0.05).6.Colorectal cancer group cases have a higher percentage of family history of cancer,and the differences are statistically significant(P<0.05).7. Polyps relapse: Polyps > 1.0 cm in diameter, multiple polyps, age > 60 years old and adenomatous polyp recurrence more easily(P<0.05).8.telephone follow-up results shown: endoscopic treatment of colorectal polyps in patients with colorectal cancer was not occurred nearly ten years,and the differences are statistically significant(P<0.05).Conclusions: The retrospective case-control study showed that age greater than 60, bloody and fecal occult blood positive,merge history of gallbladder and the appendix disease, like eating fatty food,family history of cancer patients increased the risk of colorectal cancer. Along with the aging population increases gradually, colon polyp patients have increased trend in China in recent years. This phenomenon should be paid attention during clinical physicians, especially for the patients with high-risk groups. They should be suggested to have regular colonoscopy. If you find polyps, endoscopic polyps resection treatment is necessary. endoscopic treatment of colorectal polyps in patients with colorectal cancer was not occurred nearly ten years. Polyps > 1.0 cm in diameter, multiple polyps, age > 60 years old and adenomatous polyp recurrence more easily.In addition, timely screening can obviously improve the prognosis of patients with colon polyps, especially for high-risk groups.