Correlational Research Of Vitamin D And End-Organ Damage In Patients With Essential Hypertension

Objective:To compare the serum vitamin D levels of different risk stratification in patients with essential hypertension,and to explorethe clinical significance of the relationship between vitamin D level and end-organ damages of patients with essential hypertension.Methods:A total of 118 patients diagnosed as essential hypertension were participated in the study.According to standard,all the patients included in the diagnostic standard of the primary hypertension risk stratification were divided into four groups: 23 cases in the low risk group,25 cases in the moderate risk group of, 32 cases in the high-risk groups and 38 cases in the extremely dangerous group,and 30 normal controls enrolled in the study.Acquisiting the blood of patients admitted to hospital in the morning on an empty stomach, and centrifugating blood serum.Serum vitamin D levels of all the cases were evaluated by chemiluminescence method.Comparing the differences of serum vitamin D levels between five groups and the correlation between vitamin D levels and carotid intima-media thickness(IMT)、left ventricular mass index(LVMI)and Gensini score were analyzed.Results :①The levels of vitamin D in patients of essential hypertension were lower than that in the normal controls[(27.88±5.34)ng/L,(23.05±6.74)ng/m L,(19.31±8.08)ng/m L,(17.36±2.66)ng/m L vs(30.08±4.77)ng/m L,(P<0.05)],the high risk group andhypertension were significantly lower than other groups. Different levels in patients with carotid plaques differences between serum vitamin D levels. ②With the increase of patch level,gradually reduce the serum levels of vitamin D( P<0.05).Lines of coronary angiography in patients with Gensini score. ③Lines of coronary angiography in patients with Gensini score.The score is between 10 to 72 points, with 20 points and 40 into community is divided into three groups.Serum vitamin D levels in the Gensini score > 40 points subgroups are less than 10 ~ 20 points in the group and 20 ~ 40 points subgroups[( 11.06±3.97) ng/m L,vs( 17.13±0.36) ng/m L,( 15.13 ±1.05) ng/m L,( P<0.05) ],but in the Gensini score in 10 ~ 20 and 20 to 40 minutes no statistical difference between the two subgroups(P>0.05).Single, double, three groups of vascular lesions there was no significant difference of serum vitamin D levels(P>0.05),but three vascular pathological changes of serum vitamin D level is low.④There exist a negative correlation between vitamin D level and left ventricular mass index, suggesting that vitamin D deficiency plays a role in hypertension ventricular remodeling.⑤The vitamin D levels in the extremely dangerous group and the high-risk levels was negatively related to IMT 、LVMI and Gensini score(b=-4.849、-0.061、-0.034,P<0.10).Conclusions:(1) serum vitamin D levels, patients with essential hypertension, and negatively correlated with the degree of danger of high blood pressure, and with the degree of hypertension risk, reduced levels of vitamin D is more significant.(2) vitamin D levels is negatively correlated with carotid intima- middle thickness, and changes along with the level of carotid plaques, and can be used as an early indicator of carotid artery atherosclerosis.(3) Vitamin D and coronary artery stenosis degree negative correlation between the Gensini score of the quantitative indicators, prompt the progress of the vitamin D in coronary lesions.(4) Vitamin D deficiency can be used as an important warning sign of the terminal target organ damage of hypertension, clearing the relationship between hypertension target-organ damage and chronic inflammation, improves the clinical doctorsand at higher risk for hypertension prevention and treatment of understanding, reducing the morbidity of hypertension.