| Objective:By selecting different drugs, treatment refractory diabetic foot wounds, wound healing was observed, the new method for the treatment of diabetic foot wounds refractory to explore.Methods:120 patients met the inclusion criteria of the foot in diabetic patients were randomly divided into: control group(A), low-dose insulin group(group B), GM-CSF group(group C) and small metering insulin + GM-CSF group(group D), each group of 30 cases. Later, because of the subjective and objective reasons can not continue clinical trials research object culling, eventually entering the statistical analysis of the number of cases in the control group 29 cases, 28 cases of low-dose insulin group, GM-CSF group27 cases, insulin + GM-CSF group of 28 cases. 3,15,26,40,51 days after observation and treatment of wounds.Results:1.The overall wound healing: D group in the process of wound healing secretions and the remaining three groups less and relatively clean, wound healing rate in the first,15,26,40,51 day were higher than the other three groups, with a statistically significant difference(P<0.05).2.Each group is completely wound epithelialization time was A group(105.5±1.4)d, group B(76.3±1.9) d, C group(75.6±2.0) d, D group(49.3±1.7) d, where D group healing time lower than the other two experimental groups, and much lower than the control group, the difference between groups is statistically significant(P<0.05).3.By comparing the diabetes clinical classification of these factors found clinical the higher the grade, the longer the healing time required.Conclusion:The low-dose insulin and human recombinant granulocyte- macrophage colony-stimulating factor(rh GM-CSF) in combination with, you can better treat refractory diabetic foot wounds. |
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