Talking Over The Worth Of Procalcitonin,C-Reactive Protein And White Blood Cell Count In Children With Central Nervous System Infections

Objective:Detection of standard of Calcitonin former, C- reactive protein(CRP) get along with White blood cell count(WBC) in young one with suppurative meningitis, viral meningitis.Investigating the diagnostic worth of procalcitonin(PCT), C-reactive protein(CRP) get along with white blood cell count(WBC) in young one with viral encephalitis and suppurative meningitis.Methods:From January 2013 to February 2014, 86 cases of young one with urgent encephalitis,meningitis were collected from neurology ward in Children’s Hospital of Shanxi Province.Of which 59 examples of suppurative meningitis, 27 cases of virus encephalitis were choosed as the watching group. The control group include 30 cases of non-infection children in hospital. The purulent meningitis group was divided into for the severe group and normal group. These children C reactive protein(CRP) in serum were gauginged by quantitative method, employing enzyme linked fluorescent technique gauginged procalcitonin(PCT). Respectively compare the distincts among the index group. Drawing the White blood cell count ROC curve, C- reactive protein ROC curve get along with procalcitonin ROC curve, in keeping with comparing the AUC among each index in diacrisis of suppurative meningitis, and analyzing the ROC curve for studying.Constructing information was adhibited by SPSS19.0 professional census software, have census importance, indicated by P<0.05.Results:Patients’ time of life, sexual in suppurative meningitis group, viral meningitis and contrast organize displayed no obvious difference(P>0.05). Patients are in suppurative meningitis had obvious above the average serum WBC than those of viral encephalitis(P<0.05). But without obvious distinct was discovered get the viral encephalitis along with contrast organize(P>0.05). Patients are in suppurative meningitis had obvious above the average CRP than those of viral encephalitis(P<0.05); Patients be in virus encephalitis had obvious above the average CRP than patients in the contrast organize(P<0.05). Patients are in suppurative meningitis had obvious above the average serum PCT than patients in the viral encephalitis group(P<0.05). But without obvious distinct was discovered get the viral encephalitis along with contrast organize(P>0.05). Patients are in suppurative meningitis existsd obvious above the average cerebrospinal fluid PCT than patients in the viral encephalitis group(P<0.05); But without obvious distinct was discovered get the viral encephalitis along with contrast organize(P>0.05). The WBC levels of children were not found significant difference between severe group and ordinary group with bacterial meningitis(P>0.05). The CRP levels of children in the severe group were significantly higher than those in the ordinary group with bacterial meningitis(P<0.05). The serum procalcitonin standards among children are living the severe group were obvious above the average than those remain ordinary organize with bacterial meningitis(P<0.05). The cerebrospinal fluid PCT levels of children in the severe group were significantly higher than those in the ordinary group with bacterial meningitis(P<0.05). Serum PCT of the proportion beneath the ROC profile was 0.964(P<0.001, 95%CI: 0.924﹣1.000), which is the biggest of all. The AUC of CRP was 0.894(P<0.001,95%CI: 0.819﹣0.969), the AUC of CSF PCT was 0.850(P<0.001, 95%CI: 0.754﹣0.947), while the AUC of WBC is 0.767(P<0.001,95%CI: 0.662﹣0.872) is the smallest in diagnosis of purulent meningitis.Conclusions:Serum procalcitonin can be proved to be the effective clinical indices amongdifferential diagnosing central nervous system infection as well as C-reactive protein get along with white blood cell count. The joint detection, can improve distinguish capability between virus and bacillosis infection. PCT is a good diagnostic indicator index for suppurative meningitis, can be bestowed to estimate the ponderance of the communication,guide clinical medication and reducing the risk of misuse of antibiotics at the same time.