The Relationship Between Subfoveal Choroidal Thickness And Both Choroidal Hemodynamic Index And Glycosylated Hemoglobin In Diabetic Subjects

Objective:To investigate the relationship between the subfoveal choroidal thickness(SFCT)and both choroidal hemodynamic index and glycosylated hemoglobin in diabetic subjects.Methods:78 patients(156 eyes) from ophthalmology and endocrinology ward of our hospital were enrolled in this study,including 39 females and 39 males,with a mean age of(59.8±6.2) years.According to ETDRS diabetic retinopathy grading method,samples are divided into no diabetic retinopathy group,mild or moderate nonproliferative diabetic retinopathy group,severe nonproliferative diabetic retinopathy group and proliferative diabetic retinopathy group.The SFCT and choroidal hemodynamic index were measured by enhanced depth imaging optical coherence tomography(EDI-OCT) and Color Doppler Imaging.Record glycosylated hemoglobin content of all samples.Using multivariate linear regression to analyse the relationship between the subfoveal choroidal thickness(SFCT) and both choroidal hemodynamic index and glycosylated hemoglobin.Results:The end diastolic velocity(EDV) was significant higher and the SFCT was significant thinner in NDR group than other groups.there was no significant difference of peak systolic velocity(PSV) between four groups.The resistance index(RI) was significant higher in severe NPDR group than NDR group and mild ormoderate group,the RI in PDR group was hihgest than other group with statistically significance.The SFCT was correlated positively(b=0.540 p < 0.001) with the glycosylated hemoglobin. No significant correlation was found between the SFCT and the choroidal hemodynamic index.Conclusions:Our results suggested that there were no significant correlations between the SFCT and the choroidal hemodynamic index; glycosylated hemoglobin was one of the factors that affect the SFCT in diabetic patients.