The Comparative Study Of Cerebral Microbleeds Befor And After The Treatment Of Urinary Kallidinogenase For Acute Cerebral Infarction

Objective Cerebral microbleeds(CMBs) are small chronic brain hemorrhages as the main feature of substantial subclinical damage, which are likely caused by structural abnormalities of the small vessels of the brain.Patients with ischemic stroke have a higher incidence,which was significantly higher than the healthy elderly population.In this paper,a prospective cohort study was to ivestigate the clinical significance of urinary kallidinogenase therapy to acute cerebral infarction with CMBs.Methods 57 patients with acute cerebral infartion had been admitted in the Neurologieal Department of Union Hospital from September 2014 to April 2015,all patients received treatment of urinary kallidinogenase within 48 hours of admission,and all patients had been scanned with MRI and GRE series before the therapy of urinary kallidinogenase.According to the existence of CMBs,the patients fell into two groups,CMBs group and non-CMBs group.CMBs group was recorded in items:CMBs focus number,CMBs location and number.lacunar infarction number,leukoaraiosis situation,blood pressure blood lipds,blood glucose,and others were recorded in two groups of patients.All patients were treated with urinary kallidinogenase for injection.After treatment for three weeks,the patients were rescanned with MRI and GRE to observe and compare the total number and location of CMBs,the incidence of hemorrhagic transformation and to expllore the risk factor for CMBs in acute cerebral infarction.All data were analyzed using SPSS 19.0 software.Result CMBs distributed in various regions,most often in the basal ganglia.CMBs occurrence significantly associated with hypertension(OR=6.673,95%CI=1.595-30.049, P<0.05), lacunar infarction(OR=9.089,95%CI=1.951-42.355,P<0.05) and leukoaraiosissituation(OR=5.378,95%CI=1.219-23.728,P<0.05).but did not relate with high blood lipids,uric acid, creatinine, smoking, drinking, sex, age(P>0.05).The non-CMBs group had none new occurrence in CMBs after three weeks of treatment.In CMBs group,there was no significant difference in the total number and location before and after treatment(P>0.05). All two groups of patients had no hemorrhagic transformation.Conclusion CMBs has a higher incidence in acute cerebral infarction patients,CMBs is associated closely with hypertension,lacu Inr infarction and leukoaraiosis.Within 3 weeks,the therapy of urinary kallidinogenase in acute cerebral infarction patients with CMBs does not augment the incidence of CMBs and CMBs does not augment the hemorrhagic risk of urinary kallidinogenase treatment.