The Experimental Study On Attenuating And Synergic Effects Of Kaempfer Dutchmanspipe Root Compatibility Hops

Objective:It’s often seen that nephropathy caused by Aristolochia cinnabarina as well as other aristolochia herbs in the clinic.It is so-called aristolochia acid nephropathy(AAN). The main toxin ingredient is aristolochie acid(AA)。The study is under the guidance of traditional Chinese medicine that thinks compatibility of formula could detoxify. Compatibility with different proportion of hops extracted cinnabarina content of aristolochic acid A, to determine the proportion of its effec tive range of compatibility; the same time by identifying the range of compatibilit y analgesic synergy cinnabarina study.The experiment reveals that the toxin of Ari stolochia cinnabarina could be reduced by combined with certain herbs.And we p robe into the mechanism of the detoxify function. We wish the result could guida nce clinic to prevent and treat with AAN.Methods:By HPLC with the extraction of aristolochic acid A to select the b est ratio of compatibility, through the classic anti-inflammatory, analgesic experime nts to explore the compatibility of cinnabarina hops synergies.Results:cinnabarina compatibility Hops can effectively reduce the proportion of1:5, the extraction process Zhushalian the content of aristolochic acid A, while t he other percentage of compatibility also the content of aristolochic acid A have a certain influence, but failed to demonstrate significant.Compatibility cinnabarina herbs and hops in the same cinnabarina portfolio pr eparation process, the same dose of aqueous extract had obvious anti-inflammatory and analgesic effects. However, with the compatibility of combinations cinnabarin a.There was no significant difference. This shows the compatibility cinnabarina ho ps in the anti-inflammatory, analgesic efficiency is not very significant role.Conclusion:Through experimental research, hops and cinnabarina compatibilit y of aristolochic acid A can effectively reduce the amount of fried, can effectivel y reduce the toxicity of cinnabarina medicine, this study may be of clinical use o f drugs cinnabarina herbs useful reference, in the actual treatment can be Conside r the group of medicines containing prescription cinnabarina adding a certain perc entage of the hops to be used to constrain cinnabarina medicine toxicity.