The Study Of Brimonidine Tartrate Ophthalmic Thermosensitive In Situ GEL

Brimonidine tartrate is a new highly selective a2-adrenergic receptor agonists, selective receptor than clonidine a2-high 7 to 12 times, is used to treat the complicted open-angle glaucoma drugs. The current sale only eye drops.Situ gel administration is one of the more ocular dosage form, the temperature-sensitive in situ ophthalmic gel during storage and prior to administration of a solution state, dropped in the eyes due to changes in the ambient temperature causes the polymer solution phase transition occurs, to form a gel. Prolonged drug residence time in the eye, local absorption increases, which can efficaciously decrease the irritation of certain drugs through the nasal lacrimal duct into the nose and mouth, to some extent, increased bioavailability, reduce patient discomfort.Poloxamer is the application of a polymer material for preparing more temperature-sensitive in situ gel present, it contains a hydrophobic and a hydrophilic block structure, due to temperature change alters its internal hydrogen bonding or hydrophobic interactions which result in physical form changes.Contents of this paper include:(1) to study brimonidine tartrate ophthalmic prescription with temperature-sensitive gel screening; (2) research quality of brimonidine ophthalmic temperature-sensitive gel tartrate bromine; (3) to investigated brimonidine tartrate ophthalmic temperature-sensitive stability of the gel; (4) Irritation study conducted brimonidine tartrate ophthalmic temperature-sensitive gel.This paper has been prescribed design, which design-response surface methodology for P407 and P188 prescription dosage to optimize the design,to select the best dosage.In this paper, use the UV method to establishment of a design for the conclusion, in the effective detection range was a good linear relationship, recovery, precision and constancy of the solution were eligible. The effects of brimonidine tartrate ophthalmic quality with a temperature-sensitive gel, the appearance of yellowish green transparent gel, pH was measured with an average pH of 6.41, with an average dynamic viscosity, content, etc., were eligible.To study the Brimonidine tartrate ophthalmic which using temperature-sensitive in situ gel factors, accelerated testing, and found that unsTab in the high temperature 60℃ and strong light, which should shading, cool place to save.Brimonidine tartrate ophthalmic gel in situ temperature-sensitive in vitro irritation study found that non-irritating to the eye.