The Response Of Neuron Specific Enolase (NSE) In Patients With Decompensated Heart Failure Caused By Acute Myocardial Infarction

Objective In clinics, some patients with acute ST-segment elevation myocardial infarction (STEMI) suffer from disturbance of consciousness caused by acute injured myocardium and reduced cardiac function. This study attempted to explore the quantification of cardiogenic damage of brain by the changes of serum neuron specific enolase (NSE) in acute decompensated heart failure due to acute myocardial infarction.Materials and methods 163 patients with acute ST segment elevation myocardial infarction were selected. The study group contains 46 patients with decompensated heart failure symptoms, and the control group contains 117 patients without symptoms. NSE was measured in the acute phase of myocardial infarction at admission and the stable phase before discharge. The serum troponin T (cTnT) brain natriuretic peptide (BNP)、c reactive protein (CRP)were also examined.Result In the study group, NSE was 20.07±1.09 ng/ml at admission versus 6.57±0.21 ng/ml before discharge (p<0.01). In the control group, NSE was 8.0±0.52 ng/ml at admission versus 7.01±0.64 ng/ml before discharge (p<0.05). When comparing study group with control group, NSE increase significantly in the study group than in the control group at admission (p<0.01), and no significant difference was found between the two groups before discharge.Conclusion In this study, the serum NSE concentrations increased in patients with acute decompensated heart failure. Indicating that brain damage might be quantified by NSE in patients with decompensated heart failure.