The Relationship Between Red Blood Cell Distribution Width And Heart Failure

Objective:To investigate the relationship between patients with chronic heart failure RDW, NT-pro BNP and LVEF and heart function classification.Methods:According to the NYHA grading standards,210 cases of heart failure patients were divided in to II(N=70)、III(N=70 and IV (N=70) grades,all patients were divided into cardiovascular event group(N=92)and non event group(N=108). At the same time,170 healthy persons were served as control group.According to the quartiles the RDW were divided into Q1, Q2, Q3 and Q4 groups.The LVEF was determined by three dimensional doppler echocardiograph, the RDW was determined by automatic blood cell analyzer, and the NT-pro BNP was detected by luminescence immunoassay technology.Results:①The levels of RDW were significant differences among the heart function Ⅱ, Ⅲ and IV grades(P<0.001).There were positive correlation in RDW and NT-pro BNP(P<0.001), but there were negative correlation in RDW and LVEF(P<0.05).②The RDW, LVEF and NT-pro BNP were significant differences between cardiovascular event group and non event group(P<0.05). COX regression analysis showed that RDW and NT-pro BNP are independent risk factors in cardiovascular event group.③The 14.35% as a RDW cut off value, Kaplan-Meier survival curves showed that the survival time,readmission and occurrence of cardiovascular events were significance differences between the two groups(P<0.001)。④Compared with RDW and NT-pro BNP, the incidence of cardiovascular events was higher in the RDW Q2 period than that the NT-pro BNP(P<0.001). the RDW quartilesConclusion:①RDW can be used as a convenient and useful adjunct indicator for assessing the severity of heart failure. ②RDW and NT-pro BNP are independent risk factors of cardiovascular event.