The Dose-effect Relationship Of Intravenous Dexmedetomidine Sedation For Patients With Sepsis

Objective:To observe the dose-effect relationship of dexmedetomidine sedation for sepsis, and further to determine its ED50 and ED95.Methods:Two hundred and twenty patients with sepsis were randomly divided into 6 groups. These patients received the initial dose of dexmedetomidine (1μg/kg/h) for 15min, and then received different continuous doses (0.2μg/kg/h,0.3μg/kg/h,0.4μg/kg/h, 0.5μg/kg/h0.6μg/kg/h,0.7μg/kg/h) for 12 hours. RASS score for each patient was evaluated per hour. Successful sedation was defined that RASS score remained at -2-0 and the dose of dexmedetomidine was unchanged within 12 hours. Probit regression methods were used to calculate the ED50 and ED95.Results:The ED50 of dexmedetomidine sedation in patients with sepsis was 0.559μg/kg/h, and the ED95 was 1.795p.g/kg/h.Conclusion:The recommended sedation dose of dexmedetomidine was 0.5μg/kg/h to 0.7 μg/kg/h in patients with sepsis.