Effect Of Non Alcoholic Fatty Liver On Sex Hormones In Male Patients With Type 2 Diabetes Mellitus

ObjectiveTo observe the effect of non alcoholic fatty liver disease on sex hormones in male patients with type 2 diabetes mellitus.MethodsUse a cross-sectional study methods, from November 2014 to May 2015,98 casees of male patients with type 2 diabetes who were hospitalized in Central Hospital of Zaozhuang Mining Group were studied.According to the history,physical examination, islet function, biochemical examination and liver ultrasound, diagnosed of type 2 diabetes mellitus, and the patients were divided into NAFLD group and no NAFLD group according to the liver ultrasound examination results.According to the statistical description of nonalcoholic fatty liver, the data of normal distribution were expressed by (x±S).The normal distribution of the variables in each group was tested, and the independent sample t test was used in the two groups.Multivariate analysis using Spearman correlation and Kendall correlation analysis, multiple stepwise regression analysis method for analysis of sex hormone independent factors.SPSS 17.0 statistical software was used in all analysis.The difference was statistically significant with P<0.05.Results1.The, TC, LDL-C, TG, HDL-C and FINS in the male type 2 diabetes group with non alcoholic fatty liver were significantly higher than those in the alcoholic fatty liver group, the difference was statistically significant (P< 0.01).2.The average level of total testosterone in male type 2 diabetic group with non alcoholic fatty liver was significantly lower than that in alcoholic fatty liver group, and the average level of FSH in non alcoholic fatty liver group was significantly higher than that in alcoholic fatty liver group, the difference was statistically significant (P< 0.05).3.SHBG was negatively correlated with non alcoholic fatty liver, and the correlation coefficient was r=-0.220, p=0.008. Total testosterone was negatively correlated with BMI and non alcoholic fatty liver disease. The correlation coefficient -0.199 was r and-0.267, the P values were 0.049 and 0.001, respectively, and the P values were less than 0.05.Prolactin (PRL) and alanine aminotransferase and aspartate aminotransferase were positively related to correlation coefficients r were 0.204 and 0.257, P were 0.044 and 0.011, P< 0.05.Follicle stimulating hormone was positively correlated with non alcoholic fatty liver, and the correlation coefficient was r=0.294, p=0.000. HOMA-IR was negatively correlated with age, and the correlation coefficient was r=-0.223, p=0.039.HOMA-IR was positively correlated with diastolic blood pressure, non alcoholic fatty liver, fasting insulin, fasting blood glucose, glycosylated hemoglobin, blood glucose of 2 hours after meal, the correlation coefficient r were 0.298,0.288,0.855,0.666,0.253,0.302, P value was less than 0.01.4.Non alcoholic fatty liver was the independent related factor of serum total testosterone, related index r2=-2.246, P< 0.05; glycosylated hemoglobin was the independent related factor of estradiol, the correlation index r2=-8.220, P< 0.05.AST and systolic blood pressure were independent risk factors of prolactin, correlation index r2=2.510,1.067, P< 0.05.5.Non alcoholic fatty liver, alanine aminotransferase, low density lipoprotein and systolic blood pressure were the independent related factors of follicle stimulating hormone, and the related factors were r2=2.576,-0.051,0.819,0.038, P< 0.05 or 0.01.ConclusionsNon alcoholic fatty liver disease in male type 2 diabetic patients with sex hormone binding globulin, total testosterone and follicle stimulating hormone.