Clinical Study Of Serum A-FABP, Visfatin Levels And Insulin Resistance In Newly Diagnosed Type 2 Diabetes

Objective: To detect the fasting serum adipocyte fatty acid binding protein level of(A-FABP) and visceral fat hormone(visfatin) in type 2 diabetes, analyze the relationship between the two factors and their correlation with and related metabolic indicators, and to explore the relationship between the two factors and insulin resistance.Methods: According to 1999 WHO diabetes(DM) diagnostic criteria, 80 cases of newly diagnosed type 2 diabetes(Diabetes Mellitus, DM), and and 40 cases of normal controls(NC) were enrolled, whose age and BMI were matched; serum A-FABP and visfatin levels were detected by enzyme-linked immunosorbent assay; body mass index(BMI), waist circumference(waist circumference, WC), hip(hip circumference, HC), WHR(waist-to-hip ratio, WHR), waist to height ratio(Waist-to-height ratio, WHt R) and other relevant indicators were also measured;the insulin resistance index,HOMA-IR evaluation of insulin resistance was calculated. Medical statistics and correlation analysis were performed through SPSS 17.0 software.Results:(1) The serum levels of the A-FABP were 120.82 ± 25.29ng/L in newly diagnosed type 2 diabetes mellitus(DM) and 49.47 ± 23.45 ng /L in normal controls(NC) respectively; the serum visfatin levels were 47.32 ± 4.10 μg/L in newly diagnosed type 2 diabetes mellitus(DM) and 27.52 ± 5.38μg/L in normal controls(NC) respectively; The concentrations of serum A-FABP and visfatin in DM group were higher than that in the NC group, but there was no statistical significance(P<0.05);(2) Correlation analysis showed that the concentration of A-FABP was positively correlated with that of visfatin in DM group, and also positively correlated with WC, WHR, TG, WHr T, FINS, HOMA-IR; and was negatively correlated with that of HDL-C.And further step by step multivariate regression were analyzed in which A-FABP, visfatin were as the dependent variable, and WC, WHR, TG, WHr T, FINS, HOMA-IR were as independent variables. A-FABP / visfatin, WHR, HOMA-IR were calculated in the regression equation.Conclusion:(1) Serum A-FABP and visfatin levels of DM group were significantly increased compared with the NC group, suggesting that the occurrence and development of type 2 diabetes was associated with the levels of A-FABP and visfatin.(2) The levels of A-FABP and visfatin was positively correlated with insulin resistance and may be closely related to insulin resistance and endothelial cell dysfunction.