Comparison Of Oxycodone And Fentanyl For Postoperative Intravenous Patient-controlled Analgesia After Laparoscopic Radical Resection Of Rectal Cancer

Objective: We planned to compare the effects of oxycodone and fentanyl for postoperative intravenous patient-controlled analgesia after laparoscopic radical resection of rectal cancer.Methods: It involved 60 adult patients between the ages of 40-65 who had been classified as American Society of Anesthesiologists(ASA) physical status 1 and 2, were randomly assigned to the administration of either fentanyl or oxycodone using IV-PCA(potency ratio 1 : 40).Waiting for the pain degree of all patients at the same standard after tracheal extubation, which the NRS being four, the pumps of postoperative patient-controlled intravenous analgesia were installed via intravenous infusion pathways. The NRS scores, 1,6,12,24,48 hour after analgesia at rest and movement time PCA demends were compared. The total times of self-controlled analgesia, the cumulative PCA dose administered in patient-controlled mode(PCM) and the time point of firstly given remedial analgesic drugs for analogue during the initial 48 hours after analgesia were measured. Patients were also assessed for postoperative pain severity, adverse effects, and patient satisfaction.Results: Compared with group F, the NRS scores, when 6 hour and 12 hour after analgesia at the movement time were significantly decreased in group O(p<0.05). There are statistically significant differences in the total times of bolus in IV-PCA, the cumulative PCA dosage of opioids administered in PCM, the time point of firstly given remedial analgesic drugs for analogue, the incidence of nausea and drowsiness, and the patients’ satisfaction of IV-PCA.Conclusions: In this concentration of IV-PCA pump, namely oxycodone is 8ug/(kg?ml) and fentanyl 0.2ug/(kg?ml)(potency ratio 40 : 1), oxycodone can better control the occurrence of postoperative pain, laparoscopic radical resection of rectal cancer. Oxycodone is also with lower incidence of nausea, drowsiness and higher satisfaction of IV-PCA. Further studies in various clinical settings will be needed to determine the doses of using oxycodone and the adequate potency ratio.