Studty On Changes Of Cortisol In Diabetic Ketoacidosis And Hyperglycemic Hyperosmolar Syndrome

Objective:Hyperglycemic hyperosmolar state and diabetic ketoacidosis can occur when blood glucose, increase serum sodium, accompanied by blood cortisol levels increased and is easy to be misdiagnosed for cortisol histiocytosis. Through the dynamic observation of the change trend of both diabetic emergencies blood cortisol, cortisol and increased disease characteristics of the changes of the serum cortisol were compared and analyzed. Combined with the after treatment, blood glucose, serum sodium change characteristics, and cortisol increased disease mutual authentication, for the clinical of differential diagnosis and provide a reference Methods:Random selected no acute complications of 40 cases of patients with type 2 diabetes mellitus, diabetic ketoacidosis or hyperglycemia hyperosmotic state in 38 patients(including blood sodium increased group(18 cases), blood sodium normal group 20 cases) were measured at 8, 16, 24 blood cortisol(COR), fasting blood glucose(FBG), fasting C peptide, 2 hours postprandial C peptide, serum sodium level. And after the treatment of two weeks, compared the review of the results with the before.After one month follow-up of type 2 diabetic emergencies group blood cortisol levels. Results:In type 2 diabetic patients without acute group, blood cortisol were normal at different time periods. Type 2 diabetes with acute group 8, 16, 24 when the blood cortisol than non emergency group, the difference was statistically significant(P < 0.05), but the rhythm is normal; There was no significant difference in plasma cortisol(P > 24) between 8 and 16 when the acute blood sodium level of type 2 diabetes was higher than that of the normal group. After the treatment of type 2 diabetes mellitus, the normal levels of serum sodium, fasting blood glucose and serum cortisol were significantly lower than before treatment, the difference was statistically significant(P < 0.05).After one month the diagnosis of type 2 diabetic emergency group of blood cortisol were returned to normal. Conclusion:Hyperglycemic hyperosmolar state and diabetic ketoacidosis in each period of blood cortisol were significantly increased, but normal cortisol rhythm, returned to normal after treatment, blood sodium, blood cortisol and fasting blood glucose was significantly decreased, and cortisol increased disease blood cortisol rhythm anomaly identification.