| T2DM is one of the major chronic diseases threatening human health. It is a metabolic disease characterized with high blood glucose. In recent years, the incidence of diabetes is on the rise and it has become the most challenging health problems of 21 st century. Hyperglycaemia causes the metabolic abnormalities, leading to large blood vessels and microvascular lesions, severe heart, brain, kidney, eye, nerve complications. Cerebral infarction, as one of the diabetic vascular lesions, is closely associated with diabetes. With the aging process of China’s society, T2 DM with cerebral infarction has become a common disease that threatens the life and health of old people. So the early prevention of T2 DM with cerebral infarction is important. Objective:Our study aims to analyse the characteristics of messages and clinical biochemistry indications of patients with T2 DM and cerebral infarction. So as to help finding this disease ealier and treating in time, improving the quality of patients’ life. Materials and Methods:The research data are selected from First Bethune hospital of Jilin university from January 2015 to October 2015. There are 167 patients diagnosed with T2 DM or T2 DM with cerebral infarction. 117 healthy adults with matched age and gender are selected as control samples. All the samples are divided into healthy control group, T2 DM group and T2 DM with cerebral infarction group. Exclusion conditions include type 1 diabetes or other types diabetes and other abnormal glhcose caused by other diseases, heart failure, kidney failure or other organ failure patients, taking contraceptives, pregnant women, nursing mothers, immune system or endocrine system disease, tumor, patients with acute or chronic infection, taking lipid-lowering, folic acid, vitamin B12 and other drugs which affect blood lipid and Hcy levels for nearly three months. Methods: Measure all the subjects’ height, weight, and calculate BMI. Test and record all the objects’ biochemical indicators, including Hb A1 c, Hcy, TC, LDL-C, HDL-C, TG, CRP and UA. Statistical methods: All the analysises are done with SPSS 21.0 software. Results:(1) The deta of age and gender has no statistical difference among the three groups;(2) Comparing the index differences among three groups we find that the TG, TC, LDL-C, CRP, Hb A1 c and Hcy levels of T2 DM group are higher than those in healthy group; Various indicators divided between the two groups are compared, from where we can see that TG, LDL-C, Hb A1 c, Hcy levels of both men and women of T2 DM group are higher than that of healthy controls. The difference of TC is statistically significant only in women, CRP only in men. When we contrast T2DM+cerebral infarction group to T2 DM group, we find that the HDL-C level of T2DM+cerebral infarction group is lower than the T2 DM group(P < 0.01). T2DM+cerebral infarction group patients’ TG, UA and Hcy levals are higher than that of T2 DM group; Each index points gender comparison between the two groups, the level of TG in women has a statistically significant difference(P<0.01), and HDL-C, Hcy in men has statistically difference(P<0.05), UA of men has statistically significant difference(P<0.01).(3) The Logistic regression analysis is used in the last step. The result of screening variables is that Hb A1 c, LDL-C, HDL-C enter the regression equation. Higher LDL-C, lower HDL-C are risk factors for cerebral infarction in patients with T2 DM. Conclusions:(1) The levels of Hcy, UA and TG are all higher in T2 DM with acute cerebral infarction patients than in patients of T2 DM without cerebral infarction.(2) High level of LDL-C and low level of HDL-C are risk factors for acute cerebral infarction in patients with T2 DM.(3) Both in T2 DM with acute cerebral infarction and T2 DM without cerebral infarction, the difference of each index between different genders has different performance. |
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