Association Between IL-6 (rs1800795 G/C) Gene Polymorphisms And Adolescent Idiopathic Scoliosis.A Meta-Analysis

Study Design : Meta-analysis Objective:The purpose of this study was collecting all of the related studies and using the of method of meta-analysis to evaluate the association between IL-6(rs1800795 G/C)gene polymorphisms and adolescent idiopathic scoliosis. Summary of Background Data:In the studies about adolescent idiopathic scoliosis, there are more and more opinions about IL-6 gene polymorphisms,but there is no report in regard to the association between IL-6(rs1800795 G/C)gene polymorphisms and adolescent idiopathic scoliosis. Methods:We combined polymorphism or mutation or variant variation “genotype”,“genetic”, “allele(s)” and scoliosis and Interleukin-6 OR IL6 OR IL-6 OR interleukin 6 and rs1800795 to identify the case-control studies covered in the Medline, EMBASE, Science Direct, Web of Science, and CNKI, and Wanfang and Weipu databases.Analyzed the studies which were satisfied the selection criteria to evaluate the association between IL-6(rs1800795 G/C)gene polymorphisms and AIS. Both overall and stratified meta-analyses(by ethnicity) were performed in this study. Using the allele and genotype data, we assessed the risk of scoliosis(OR, odds ratio) with an assumption of allele G versus allele C,G/G versus C/C(homozygote model), G/C and G/C versus C/C(dominant model) and G/G versus G/C and C/C(recessive model). Results:5 original articles concerning the correlation of IL-6 rs1800795 SNP with scoliosis were considered eligible for this analysis. There were 1340 participators, among them,the patients of AIS were 557,and the controls were 783. The 5 studies from 5 different countries were composed of 3 Caucasian studies, 2 Asian studies, and 0 study without stating the ethnicity. All genotype frequencies were tested in HWE(P<0.001). Using the allele and genotype data, we assessed the risk of scoliosis(OR, odds ratio) with an assumption of allele G versus allele C,G/G versus C/C(homozygote model), G/C and G/C versus C/C(dominant model) and G/G versus G/C and C/C(recessive model). We performed a meta-analysis among cases and controls in this quantitative analysis. No association between rs1800795 SNP and AIS was indicated using the any of the models. In subgroup analyses by ethnicity, statistically significant association was also not detected in all subgroups. Conclusion:There was no association between IL-6(rs1800795 G/C)gene polymorphisms and adolescent idiopathic scoliosis. Whether in Asia or Europe, the conclusion was same.