Relationship Between Vitamin D Status And Islet Cell Function, Insulin Resistance, Lipid Level In Patients With Polycystic Ovary Syndrome

Objective:To investigate the prevalence of vitamin D deficiency in women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group. Methods:This wan an observational study on 42 women with PCOS using the Rotterdam criteria, A total of 22 in control group.Serum 25hydroxyvitamin D, fasting insulin (fins), fasting plasma glucose (FPG), postprandial blood glucose and insulin, low density lipoprotein, high density lipoprotein, triglyceride levels are examined.Homeostasis model insulin resistance index (HOMA-IR) and steady state model of islet β-cell function index (HOMA-β) are calculated, and statistical analysis. Results:There was no significant difference between fasting blood glucose levels in obese and non obese PCOS group PCOS group (P>0.05), In PCOS group, the level of serum 25hydroxyvitamin D was negatively correlated with insulin resistance index (HOMA-IR), insulin sensitivity index (QUICKI) and HDL-C.The more severe vitamin D deficiency, the more significant insulin resistance (HOMA-IR is higher, QUICKI is lower). The level of 25hydroxyvitamin D in obese PCOS patients is significant lower than other groups (P< 0.001),25hydroxyvitamin D levels and fasting blood glucose (r=-0.657), insulin β-cell function index (HOMA-β, r=-0.615), insulin resistance index (HOMA-IR, r=-0.712), quantitative insulin sensitivity index (QUICKI, r=-0.643) was negatively correlated (P< 0.001). Low 25hydroxyvitamin D levels in PCOS patients are related to IR. Conclusion: The decrease of serum 25hydroxy vitamin D level in PCOS patients is related to the increase of insulin resistance and the decrease of islet β-cell function.