The Prognostic Value Of Red Blood Cell Distribution Width To Platelet Ratio In The Patients With Severe Burn

Objective Severe burns is one kinds of acute traumatic diseases and have a high risk of mortality rate. How to evaluate the severity of the burn, and which is the best burns risk prediction biomarkers have been the central focus study for the burn practitioners.The ratio of red blood cell distribution width(RDW) to platelets(RPR) as a new index of hematology diagnosis model has been applied to chronic Hepatitis patients withhepatic fibrosisand cirrhosis, as well as a variety of diseases such as myocardial infarction and severe acute pancreatitis, However,there is no clear study suggest the association between RPR and severe burns so far. Therefore, we performed this study to evaluate the relationship between RPR the third day after admission and prognostic value in patients with burns.Methods Three hundred and twenty five adult patients with severe burn from January 2009 to December 2014 were enrolled in this study. Laboratory results of the third day postburn were obtained from medical records. The patients were divided into two groups based on the RPR of the third day after burn: high(0.124 or more) RPR group and low(less than 0.124) RPR group. Data on gender, age, burn severity, and incidence of inhalation injury were analyzed. Data were processed with chi-square, Kaplan-Meier survival analysis, Cox regression analysis, and draw receiver operating characteristic(ROC) curve of RPR value for 61 severe burns death patients.Results The in-hospital survival rate of high RPR group and low RPR group were 70.2% and 93%, respectively. The difference was very significant(P<0.01). Cox regression analysis suggested that the third-day RPR(HR:0.398; 95%CI: 0.200-0.794) was an independent prognosis indicator for severe burns(P<0.01). The ROC curve analysis in patients with 61 deaths showed that the total area of the third-day RPR was 0.776(95% CI:0.706-0.846,P<0.01) and 0.192 was the cutoff value of the third-day RPR(sensitivity: 62.3%, specificity: 86.3%).Conclusion The third-day RPR can be used as an independent prognostic indicator for patients with severe burn.