The Curative Effect Of Three Kinds Of Joint Injection Drug Treatment Of Infantile Hemangioma

Background:Hemangioma is the most common benign tumor of infants and young children, the incidence of about 4%-4%, good hair to the head and neck, men and women come on a ratio of 1:(3-5), pathogenesis is not clear at present, the main and promoting angiogenesis factor, inhibiting angiogenesis factor and other factors. Clinical stages:the stage hyperplasia, fade, fade to complete. Pathological characterized by excessive hyperplasia period skin cells proliferation, cell density increased, fading period skin cells apoptosis and normal form. In the first six months of diseases, the rapid growth of the tumors had subsequently slowed, began to fade after to 1 one full year of life, to 9 years old or so, most of the children with tumors can be completely subsided. Although the disease has a tendency to regress, but due to hyperplasia period hemangioma prone to complications such as ulcers, bleeding, infection, necrosis, cause secondary deformity, functional obstacle, affect beautiful, etc. Hemangioma treatment method are many, including medication, cryotherapy, radiation therapy, laser therapy, surgical therapy and minimally invasive therapy, etc. Treatment mainly includes the purpose of inhibiting tumor growth and promote the two aspects of tumor regression. Stressed the multi-disciplinary comprehensive treatment at home and abroad, the method of hemangioma is the most commonly used in clinical drug treatment, can also be used as a minimally invasive surgery and treatment of AIDS. Drug treatment dosing method are many, the most common including oral, besmear outside and closed injection. Injection of drugs for the treatment of the most commonly used include represented by pingyangmycin antitumor drugs, with dexamethasone, triamcinolone acetonide, represented by the depot loose hormonal drugs and represented by poly cinnamyl alcohol blood vessels hardener in clinical application closed injection in the treatment of infantile hemangioma is the most widespread. But the joint application of three drugs in the treatment of infantile hemangioma study is less, for the curative effect of combined use of these three kinds of drugs is better than using only one or two kinds of combined treatment of lack of evidence.Objective:The purpose of this study is through the retrospective study, evaluation by pingyangmycin antitumor drugs, with dexamethasone, triamcinolone acetonide, represented by the depot loose hormonal drugs and represented by poly cinnamyl alcohol blood vessels hardener in clinical closed injection in the treatment of infantile hemangioma efficacy and safety, for the clinical treatment of infantile hemangioma treatment plan optimization to provide data support.Method:And exclusion criteria, as defined by the collection of shandong provincial hospital burn plastic surgery on January 1,2014 to December 31,2015, during the period of hospitalization, without other treatment, pure line closed and confirmed by traces the history and the related auxiliary examination for infantile hemangioma of children, the number of cases, treatment effectiveness, the incidence of adverse reactions, dosage, treatment time, length of course of systematic review, and select the corresponding control group control study.Results:Statistical results confirm pingyangmycin, cinnamyl alcohol of triamcinolone acetonide and combined use of closed treatment of infantile hemangioma injection can significantly improve tumors present situation, including color, texture and blood flow, low incidence of adverse reactions, almost no statistical significance, and with only one or two of drug treatment, compared to shorten the duration of symptoms, reduce costs, the incidence of adverse reactions have no obvious increase at the same time, the efficacy and safety have been confirmed.Conclusion:1. Three kinds of drugs in combination with closed treatment of IH can obviously shorten the duration of hemangioma and achieve clinical cure.2. Under the two kinds of evaluation method of effective rates were significantly3. higher than that of hemangioma natural healing healing (50% of the patients at the age of five can fade or recovered completely,70% of the patients can get healed completely subsided when he was 7 years old)4. Three kinds of drugs in combination with closed treatment of IH can significantly improve tumors present situation, including color, texture and blood flow (Two kinds of evaluation method of effectiveness is 93.2% and 95.2% respectively, the cure rate were 88.5% and 85.6%, respectively)5. A lower incidence of adverse reactions, is slightly more adverse reactions, no serious adverse events occur, for the influence of routine blood almost no statistical significance.