Clinical Significance Of Nutritional Status And Nutritional Parameters During Chemoradiotherapy In Esophageal Cancer

Objective:To evaluate clinical significance of nutritional status and nutritional parameters in esophageal cancer during chemoradiotherapy.Methods: 68 esophageal cancer patients undergoing concurrent chemoradiotherapy were prospectively investigated. Patient-Genetated Subjective Global Assessment was applied to conduct regular nutritional assessment.All of the patients received early nutrition education and short-term nutritional support for severe malnutrition.Patients were divided into mild-to-moderate malnutrition group(PG-SGA(B))and severe malnutrition group(PG-SGA(C))according to PG-SGA score on admission.We collected weight,albumin(Alb),hemoglobin(Hb),white blood cells(WBC), platelets(PLT), neutrophils(NEUT), lymphocytes(LYM), peripheral mononuclear cells(PMC) and other objective nutrition indicators before and after chemoradiation to evaluate clinical significance of the change of indicators.Results:There were 24 cases in PG-SGA(B)group and 44 cases in PG-SGA(C)group.Hb and Alb before chemoradiotherapy were no difference statistically in two groups(P>0.05), Hb(x~2 = 2.710;P=0.009)and Alb(x~2 =3.743;P=0.000) after chemoradiotherapy in PG-SGA(B)group were higher than those of PG-SGA(C)group.Body Mass Index(BMI) before and after chemoradiotherapy was statistically significant in two groups(P<0.05).PG-SGA scores after chemoradiotherapy were positively correlated with the change of Hb,Alb,BMI parameters and percentage of weight loss before and after chemoradiotherapy(r=0.240,0.249,0.282,0.447;P<0.05).Conclusion:The change of Hb,Alb,BMIparameters and percentage of weight loss before and after chemoradiotherapy are the related nutritional risk factors in esophageal cancer patients after chemoradiotherapy.Severe malnutrition patients have good compliance in nutritional intervention,mild-to-moderate malnutrition has poor understanding of malnutrition.