Analysis Of Drug Resistance Of Acinetobacter Baumannii And Study On The Status Of The Production Of The Carbapenemase

Objective: To understand the clinical drug resistance, distribution of Acinetobacter baumannii in our hospital, and the change of drug resistance of Baumannii. To explore the carbapenemases in carbapenem-resistant Acinetobacter baumannii. Methods: Using retrospective method to analyze the drug resistance of Acinetobacter Bau-man from 2012 to 2015.and collected 36 strains of the carbon-resistant Acinetobacter Baumannii.Using the modified Hodge test to confirm the phenotype of these stra-ins, screening the strains of producing carbapenemases. Using PCR to detect the the genotype of the carbapenemases Results:(1) The resistant rate of Acinetobacter bau-mannii increased year by year, the high rate of resistance to commonly used antibiotics, the resistant rate of carbapenem antibiotics like imipenem and meropenem were greater than 50%.(2) Strains mainly from respiratory specimens, a total of 127 strains, accounting for 46.2%, followed by secretions, a total of 80 strains, accoun-ting for 29.1%. In terms of the distribution of the strains, Acinetobacter bauman was mainly from the intensive care unit, accounting for 37.9%, followed by respiratory department of internal medicine, accounting for 13.8%.(3)36 strains of carbon- resistant were detected, and 34 strains were positive after the modified Hodge test. 32 strains were detected to carry the OXA-23 gene After PCR amplification and electrophoresis, other genes OXA-24, IMP-1, IMP-2, VIM-1, VIM-2 were not detected.Conclusions:(1)The drug resistance of Acinetobacter in our hospital is more serious, and the bacterial resistance rate is increasing year by year.(2)Acinetobacter baumannii of carbapenemases-resistant was in severe cases, the resist rate to imipenem and meropenem were more than 50%.(3) Acinetobacter bauman in our hospital mainly produced OXA-23 type carbapenemase. The IMP type, VIM type and OXA-24 type carbapenemase were not detectcd.