The Accuracy Study Of Contrast-enhanced Ultrasonography Combined With Two-dimensional Ultrasound In The Diagnosis Of Thyroid Minimal Carcinoma

Objective: To evaluate the value of contrast-enhanced ultrasonography(CEUS)combined with two-dimensional ultrasound in the diagnosis of thyroid minimal carcinoma(TMC).Methods: Totally 593 patients with 853 suspicious nodules were consecutively enrolled into the prospective study during June 2013 and January 2015.The diameter of all nodules ranged from 0.22 cm to 1.0 cm.The ultrasound findings were compared with surgical pathology,and 7 indices including sensitivity(Sen),specificity(Spe),accuracy,positive predictive value(PV+),negative predictive value(PV-),positive likelihood ratio,negative likelihood ratio were evaluated comprehensively with the statistical method.Results: The sensitivity(Sen),specificity(Spe),accuracy,positive predictive value(PV+),negative predictive value(PV-),positive likelihood ratio,negative likelihood ratio of two-dimensional ultrasound and contrast-enhanced ultrasonography combined with two-dimensional ultrasound were83.1%/88.4%,80.1%/83.3%,82.4%/87.0%,91.7%/93.1%/,65.0%/73.7%,4.2/5.3,0.21/0.14,respectively,and the differences was statically significant.Conclusion: The accuracy of two-dimensional ultrasound already was very high,and contrast-enhanced ultrasonography combined with two-dimensional ultrasound Can greatly improve the diagnostic accuracy of thyroid minimal carcinoma.Contrast-enhanced ultrasonography shoud be used as a routine diagnostic method widely used in thediagnosis of thyroid minimal carcinoma,and it can provide instructional suggestions for clinic to select treatment or follow-up.