Analysis Of Serum MiR-21 And MiR-106a Expression In Patients With Renal Cell Carcinoma And Its Clinical Values

Objective: serum mi R-21 and mi R-106 a expression levels before and after surgery was detected and its relationship with clinical-pathological parameters was analyzed in patients with renal clear cell carcinoma(c RCC). Methods: A total of 30 serum samples from patients with c RCC were collected before surgery and after a month of surgery during the period of February of 2013 to July of 2014. Moreover,the study included 30 healthy controls. Serum mi R-21 and mi R-106 a expression levels from patients with c RCC and healthy controls were performed using the real-time PCR.Results: Serum mi R-21 expression levels of pre-operative(medium 8.34) in patients with c RCC were increased compared with healthy controls(medium 0.70,p=0.0001). mi R-21 levels of post-operative(medium 0.68) had no statistically differences compared with healthy controls(medium 0.70,P=0.256). mi R-21 levels of post-operative(medium 0.68) were significantly reduced compared with pre-operative(medium 8.34,p=0.002). mi R-106 a levels of pre-operative in patients with c RCC were also increased compared with healthy controls(p=0.0001). mi R-106 a levels of post-operative had no statistically differences compared with healthy controls(P=0.807). mi R-21 levels yielded AUC of 0.865( 95%CI: 0.766 ~ 0.965,P=0.0001) with 77.3% of sensitivity and 96.4% of specificity. mi R-106 a levels yielded AUC of 0.819(95%CI:0.710-0.929,P=0.0001) with 86.7% of sensitivity and 70.0% of specificity.Conclusions: Serum mi R-21 and mi R-106 a expression levels in patients with c RCC were significantly increased,while its levels were decreased after operative. The outcome suggested that mi R-21 and mi R-106 a levels were closely related with c RCC. The mi R-21 and mi R-106 a can be regarded as a potential molecular marker in c RCC.