The Effect Of Ammonium Persulfate And Potassium Permanganate Treatment On Biocompatibility Of Medical Metal Material

At present, the blood contact materials which is used for preparing blood-contacting devices have bad blood compatibility. It is so significant for medical value and clinical application to improve the anticoagulant of blood-contacting materials. In addition, it requires good tissue compatibility besides the better anticoagulant for implanted devices, such as cardiovascular stents and valves.Currently, it has found that reactive oxygen species (ROS) photogenerated by titanium oxide (TiO2) thin film can improve the anticoagulant of material surface. According to the fact, in this paper, ammonium persulfate (APS) and potassium permanganate (KMnO4) which could release ROS are used to treat many materials, such as silicon (Si), silica (SiO2), stainless steel (SS), titanium (Ti), etc. And then, it is studied that the effect of ROS treatment processes on materials blood compatibility and tissue compatibility.This paper includes two parts. It is mainly explored that the influence of APS treatment on surface properties of Si, SS, Ti in the firs part. The results showed:The APS treatment can effectively improve the anticoagulant of Si, SS, Ti. Under three kinds of treatment including APS (D), APS (D-UV), APS (S-UV), when the treatment time is longer and the APS concentration is larger, the anticoagulant of material is better. At the same time and concentration, the ability to improve material anticoagulant is different, APS (D-UV)≈APS (S-UV)>APS (D), and the sample Si and Ti treated by APS (D-UV) has advantages for endothelial cell growth and proliferation, except SS. The APS treatment has no obvious effect on macrophages behavior.Using the APS (M-UV), it is obtained that fibrinogen and platelet micropattern.In the second part, it is studiedd that the influence of KMnO4 treatment on surface blood compatibility and cell compatibility of Si, SiO2, SS, TiO2. The results showed:Under three kinds of treatment including KMnO4 (D), KMnO4 (D-UV), KMnO4 (S-UV), at low concentration (0.01%), KMnO4 can improve the anticoagulant of Si. With low concentration (0.01%-0.62%) and same time, the ability to improve material anticoagulant is different, KMnO4 (D-UV)>KMnO4 (S-UV)> KMnO4 (D). When the concentration is larger, range from 5% to 10%, there is no obvious difference among three ways and they can improve the anticoagulant significantly.The sample SiO2, SS, TiO2 treated by APS (D-UV) can enhance endothelial cell growth and proliferation.Using KMnO4 (D), it is obtained that platelet and endothelial cell micropattern on SiO2 surface. The treated region can inhibit the adhesion of platelet and enhance growth and proliferation of endothelial cells (ECs) to produce the cells array. Comparing to APS treatment, KMnO4 treatment, especially KMnO4(D), is an simple and effective treatment way which could not only improve material anticoagulant and enhance cell compatibility, but also use easily (no UV irradiation) and has wide concentration range.