Comparison Of The Efficacy Of Percutaneous Microwave Coagulation Therapy Combined With Transarterial Chemoembolization Or Radiotherapy Combined With Transarterial Chemoembolization In Treatment Of Advanced Primary Hepatic Carcinoma

Objective To investigate the efficacy of percutaneous microwave coagulation therapy combined with transarterial chemoembolization or radiotherapy combined with transarterial chemoembolization in treatment of advanced primary hepatic carcinoma.Methods One hundred and twenty-five patients, which were diagnosed as advanced primary liver cancer by pathology, clinical, ultrasound, CT, and laboratory parameters, were recruited from June 2010 to December 2012 in our hospital. Twenty-five patients abandoned treatment, twenty-six patients were transferred to other hospital, finally the other seventy-four patients were divided into two groups (PMCT+TACE:n=35 and radiotherapy+TACE:n=39) according to the treatment method. The tumor imaging and AFP level were recorded one month after the treatment. We also recorded the effective power and side effects of each group according to the WHO solid tumor curative effect evaluation.Results One month after the treatment, the effective rate in the PMCT+TACE group was 71.43%, of which seven patients were completely controlled, eighteen patients were partially controlled. At the same time, the effective rate was 51.28% in radiotherapy+TACE group, of which six patients were completely controlled, fourteen patients were partially controlled. The difference between the two groups was statistically significant (P<0.05). After one month of treatment, AFP of twenty-eight patients was completely recovered to normal in the PMCT+TACE group, while only twenty-one patients in the radiotherapy+TACE group returned to normal, compared with that before treatment. The difference between the two groups was statistically significant (P<0.05). The 1 year and 2 year survival rates were 80% and 65.71% respectively in the PMCT+TACE group, while that were 69.23% and 51.28% respectively in the radiotherapy+TACE group. The difference between the two groups was statistically significant (P<0.05). The radiation induced liver disease occurred in two patients in the radiotherapy+TACE group within 2 months after treatment.Conclusion Compared with radiotherapy+TACE, PMCT+TACE is more effective and practical for the treatment of advanced primary liver cancer, which provides a new therapeutic strategy for the treatment of these patients in the future.