Clinical Study Of Vesiculation Moxibustion In Preventing And Treating Allergic Rhinitis Due To Cold Deficiency Based Optimization Scheme Of Factorial Design

ObjectivesThis research is to study the precaution and remedy for allergic rhinitis of deficient cold type utilizing factorial experiments, with the sufferers of this kind of rhinitis being subjects, combining the time-based experience of external therapy and guided by the dialectical traditional Chinese medicines theory as well as the meridian theory. We apply the 2x2 factorial combination of two important factors (acupoints, medicines) that influence the Vesiculation Moxibustion treatment, aiming to find out the optimal cooperation of acupoints and medicines compatibility.Methods180 sufferers of allergic rhinitis of deficient cold type are partitioned into Al group (acupoints of deficient cold type+medicines of deficient cold type), A2 group (acupoints of normal type+medicines of deficient cold type), A3 group (acupoints of deficient cold type+medicines of normal type), A4 group (acupoints of normal type+medicines of normal type), each group with 45 sufferers. They are treated three times in the first, middle, third dog-days in 2015. The curative effect is evaluated before and after the three treatments, then statistical analysis is carried out, the observations of which are the clinical symptoms score of allergic rhinitis sufferers, nasal rhinoconjunctivitis quality of life questionnaire (RQLQ) and VAS of self-assessment of the allergic rhinitis symptom.ResultsThe total effective rate of group Al (acupoints of deficient cold type+ medicines of deficient cold type) is 97.78%; group A2 (acupoints of normal type+medicines of deficient cold type) is 82.22%; group A3 (acupoints of deficient cold type+medicines of normal type) is 84.44%;group A4 (acupoints of normal type+medicines of normal type) is 68.89%. The curative effects of four groups are tested to differ significantly (P＜0.05):via rank test of group Al with group A2, A3 and A4, there is remarkable difference (P＜0.05); via rank test of group A2, A3 with group A4, there is also remarkable difference (P＜0.05); via rank test of group A2 with A3, there’s no remarkable difference (P＞0.05).Regarding the improvement of symptoms, the symptom scores, the scores of total RQLQ and sub-items, VAS of self-assessment after treatment all have remarkable difference (P＜0.05) in four groups compared to those before treatment. Eight aspects, i. e. RQLQ regular activity, sleeping, non nasal/ocular symptoms, actual problem, nasal symptoms, ocular symptoms, emotion and total score, are verified by rank test to differ distinctly (P＜0.05) after treatment of four groups. Via rank test of group A1 with group A2, A3 and A4, there is remarkable difference (P＜0.05);group A2 and group A4 have remarkable difference (P＜0.05) in regular activity, non nasal/ocular symptoms, actual problem, nasal symptoms, ocular symptoms, emotion and total score according to the rank test; group A3 and group A4 differ notably (P＜0.05) in the sub-items and total scores of RQLQ symptoms in terms of the rank test; also, the rank test shows that there’s no statistical significance (P>0.05) between group A2 and group A3. The VAS and symptoms score of four groups have extremely significant difference (P＜0.01) after treatment according to the rank test. Via rank test of group Al with group A2, A3 and A4, there is extremely significant difference (P＜0.01); group A2, group A3 and group A4 differ notably (P＜O.05) in the comparison of VAS and symptoms score; Comparison of group A2 and group A3 has no statistical significance (P>0.05) by the rank test.In the research on combined intervention effect of medicines and acupoints, the variance analysis of total RQLQ score, each clinic symptom score, symptomatic cumulative score and VAS suggests that there’s no significant difference (P＞0.05) after the statistical treatment, and this implies that deficient symptom medicines and acupoints have no obvious interaction in the RQLQ total score, each clinic symptom score, symptomatic cumulative score and VAS score of allergic rhinitis sufferers of deficient cold type. We compare the analysis of the RQLQ total score, each clinic symptom score, symptomatic cumulative score and VAS score to explore the main effect of acupoints and medicines. On the premise of same acupoints, the group with the medicines of deficient cold type gets the lowest scores in the comparison of the RQLQ total score, each clinic symptom score, symptomatic cumulative score and VAS, and has extremely significant difference (P＜0.01) compared to group with normal medicines after statistical treatment. If the medicines are same, the group with the acupoints of deficient cold type gets the lowest scores in the comparison of the RQLQ total score, each clinic symptom score, symptomatic cumulative score and VAS, and has extremely significant difference (P＜0.01) compared to group with normal acupoints after statistical treatment. ConclusionFour groups of sufferers have different extent of improvement in clinic symptoms after a treatment course, among which group with acupoints of deficient cold type+medicines of deficient cold type is the most distinct, implying that this group has the optimal curative effect in the improvement of sufferer’s symptom with allergic rhinitis of deficient cold type. Through the combined intervention effect of medicines and acupoints, there’s no obvious interaction between them, suggesting that the medicines and acupoints exist independently.The combined application of deficient symptom medicines and acupoints overmatches the application of pure medicines or pure acupoints in the improvement of sufferer’s symptom with allergic rhinitis of deficient cold type.