Association Of Lipid-related Residual Risks And TCM Syndromes With Symptomatic Intracranial Artery Stenosis

ObjectiveTo analysis the association of the clinical data including past risk factor and lipid-related test results of patients with symptomatic intracranial artery stenosis in our hospital encephalopathy center from January 2013 to December 2014, by adopting retrospective study. To analysis the relationship between intracranial artery stenosis and multiple intracranial stenosis and severity of stenosis with risk factors and lipid-related residual risks. To study the distribution characteristic of traditional Chinese medicine syndrome, and the association between the TCM syndromes with lipid test result, in order to provide a reference for research of relationship of TCM and modern medicine and objective evaluation of TCM.MethodWith the method of retrospective study, we collect clinical data and severity of stenosis of patients with symptomatic intracranial artery stenosis in our hospital encephalopathy center including five department of neurology from January 2013 to December 2014 according to the inclusion and exclusion criteria, to analysis the association of lipid-related residual risks and TCM syndromes with symptomatic intracranial artery stenosis. Statistical analysis using SPSS 17.0 software for statistical methods chi-square analysis, ANOVA method for three groups, and we use P＜0.05 for the significant significance.Results1. we found that there is significant difference between these two groups in age, smoking, level of non-high density cholesterol. In the logistics analysis, we found stroke history, triacylglycerol and high density cholesterol make a significant difference between these two grouds.2. Statistically analysis between single vessel ICAS and multiple vessel ICAS show significant difference in age and low density lipoprotein cholesterol between these three groups.3. There is no relationship between mild group and severe steno-occlusion group in the statistically analysis.4. Among the patients with LDL-C＜2.59mmol/L, ICAS was associated with HDL-C (OR per 1 mmol/L increase:0.225, P=0.024), TG(OR for lowest vs. highest lipid tertiles:3.681, P=0.013), non-HDL-C(OR for per 1 mmol/L increased:5.291, P=0.010; OR for highest vs. lowest tertiles:4.038, P=0.012), while ICAS was not associated with TG、HDL-C、non-HDL-C among patients with LDL-C=≥ 2.59mmol/L.5. The syndrome distribution frequency from most to less was blood stasis, wind, internal heat, phlegm, Qi deficiency, yin deficiency. Blood lipid and syndrome elements had no significant different in statistics.Conclusion1. High density lipoprotein cholesterol was the protective factor for symptomatic intracranial atherosclerosis stenosis, Triacylglycerol showed Negative correlation with symptomatic intracranial atherosclerosis stenosis.2. Among sICAS patients, there is significant difference in age and low density lipoprotein cholesterol between single vessel group and mutil-vessel group.3. High TG, High non-HDL-C and low HDL were positively correlated with intracranial artery stenosis among patients with LDL＜2.59mmol/L。4. The syndrome distribution frequency from most to less as blood stasis, wind, phlegm, internal heat, Qi deficiency, yin deficiency. Blood lipid may has relationship with syndrome elements, but...