The Study On The Correlation Between Coronary Heart Disease Of Phlegm Syndrome Of TCM And Objective Index

Objective1. The study summarized the objective index through a systematic review of ancient literature as well as modern clinical research associated with phlegm retention and coronary heart disease, aimed to obtain specific objective index with diagnosis significance of phlegm retention in coronary heart disease.2. Conducting a clinical verification in local area based on objective indicators we refined through first stage.Methods1. Through a comprehensive retrieval on literature associated with phlegm retention and coronary heart disease selected the relevant literature, and, refined them based on inclusion, exclusion criteria. Finally, we used Meta-analysis to obtain specific objective index about diagnostic significance of phlegm retention in coronary heart disease.2. Cross sectional survey,100 patients with coronary heart disease were included based on diagnostic, inclusion, exclusion criteria, collected objective indicators we refined through first stage of coronary heart disease and conducted a clinical verification in local area.Results:Results1. We got 1145 literatures through a comprehensive retrieval,105 literatures were included in our study, within which 105 literature were studied by qualitative analysis,42 by quantitative analysis,58 objective indicators were obtained and were divided in 44 projects.2. A frequency of more than 10%of the 44 projects were blood lipid, coronary artery stenosis, CRP, homocysteine, and were included in quantitative analysis.3. Meta-analysis of blood lipid related project showed:there was statistical significance in the rate of TG in phlegm retention free group, Healthy people group, blood stasis syndrome group, group of qi stagnation and blood stasis syndrome and Qi and yin deficiency syndrome compared with phlegm retention group(P＜0.01). There was statistical significance in the rate of TC in healthy group, phlegm retention free group and Qi and yin deficiency syndrome compared with phlegm retention group(P＜0.01). And there was no statistical significance the rate of TC in blood stasis syndrome group and group of qi stagnation and blood stasis syndrome compared with phlegm retention group(P＞0.05). There was statistical significance in the rate of HDL in Healthy people group, phlegm retention free group and blood stasis syndrome group (P ＜0.01),but no statistical significance in group of Qi stagnation and blood stasis syndrome, or group of Qi and yin deficiency syndrome(P＞0.05).There was statistical significance in the rate of LDL in Healthy people group, phlegm retention free group, and group of Qi stagnation and blood stasis syndrome (P< 0.01), but no statistical significance in blood stasis syndrome, or group of Qi and yin deficiency syndrome compared with phlegm retention group(P＞0.05).4. The study of the degree of coronary artery stenosis showed:Patients with moderate to severe coronary stenosis were likely to have phlegm retention group or blood stasis syndrome. And there was statistical significance in comparison of phlegm retention group, blood stasis syndrome and syndrome free from blood stasis and phlegm retention group (P＜0.01), but no statistical significance in comparison of phlegm retention and blood stasis syndrome.5.The study of the CRP showed:Through Meta-analysis there was statistical significance in healthy people group and group of syndrome free from blood stasis and phlegm retention (P＜0.01), but no statistical significance in phlegm retention free group or blood stasis syndrome compared with phlegm retention group(P＞0.05).6. The study of the Homocysteine showed:there was statistical significance in healthy people group group, and group of syndrome free from blood stasis and phlegm retention(P<0.01), but no statistical significance in phlegm retention free group or blood stasis syndrome compared with phlegm retention group(P＜0.05).7. Qualitative analysis showed:The study of objective index were in the case study stage, which were not qualified to statistical combination.8. There were 7 compound syndrome types among the 100 patients included, and there was no statistical significance in comparison of phlegm retention associated syndrome and other syndrome in blood lipid (P＞0.05); but there was statistical significance in TCU TG(P＜0.01), but no statistical significance LDL HDL(P＞0.05).Conclusion1. TG had the better consistency in phlegm retention compared to other syndrome and there was statistical significance in consolidation effect, indicating we made a distinction between coronary heart disease related syndrome and other syndrome by TG. As the low level of evidence and the limited quality of original studies, this conclusion was insufficient to be fully applied into clinical practice, and more large scale and high quality clinical trials were required.2. TG could distinguish phlegm retention syndrome from phlegm retention free syndrome in coronary heart disease, which was consistent with the results of Meta-analysis. we could make a conclusion that we may use TG as specific objective index of phlegm retention in coronary heart disease in local area.