Distribution And Drug Resistance Analysis Of Pathogens In Early Urinary Tract Infection After Renal Transplantation

Objective: To analyze the urinary tract infection pathogen distribution and drug resistance after renal transplantation, and provide evidence to guide clinical practice.Methods: Retrospective analysis 101 cases of renal transplant recipients in the urine culture results within a month, urine culture positive samples a total of 196 cases in May 2010- December 2015 First Affiliated Hospital of Soochow University, with a random sample of 215 cases over the same period of Urology other hospitalized patients urine culture pathogen distribution and drug sensitivity were compared.Result: Renal transplant recipients urinary tract infection Gram-negative bacilli(86.22%), Gram-positive cocci rare(9.18%), and some fungal infection(4.59%). The inpatient urology urinary tract infection Gram-negative bacteria, Gram-positive cocci were common, accounting for 65.58%, respectively, 32.55%, fungal infections are extremely rare. Renal transplant recipients in early infection Gram-negative bacteria Escherichia coli mainly(16.84%), Citrobacter freundii(11.22%), Pseudomonas aeruginosa(9.69%), Enterococcus(9.18%), Klebsiella pneumoniae(6.12%) and the like. Gram-negative bacteria Escherichia coli representative cefuroxime, ceftriaxone, cefoperazone and other cephalosporin resistance rates as high as 80% or more, cefoperazone / sulbactam resistance up 39.39 percent, its resistance far more than other hospitalized patients resistant high; in addition, compared with the general hospital urology patients, kidney transplant recipients postoperative infection of Pseudomonas aeruginosa to imipenem higher performance(47.37% VS 10%). Gram-positive bacteria, enterococci to penicillin G, ampicillin resistance up to 80%, compared with the general hospital urology patients, their resistance to the presence of a significant difference(P <0.05).Conclusions: Gram-negative bacteria were the main pathogenic bacteria of early urinary tract infection after renal transplantation recipients, and the gram-positive bacteria were rare and often accompanied with fungal infection., bacterial resistance is high. Therefore, early post-operative renal transplantation should be rational use of antibiotics, antibiotics to cover gram-negative bacteria prevent urinary tract infections mainly, and based on urine culture and drug susceptibility results of rational use of antibiotics to reduce the generation of resistant strains.