| Objective:Through with the division of 3 years of theoretical study and clinical practice, Professor of Fujian Province 362000 for medical treatment, a variety of difficult miscellaneous diseases, especially the experience of diagnosis and treatment of cardiovascular and cerebrovascular diseases, drug characteristics and academic thoughts of systematic summary and strive to more explore the valuable academic expertise, so that more clinicians and patients benefit 0 At the same time, the clinical efficacy and safety of ADL (MMSE) and clinical dementia (CDR) were used to evaluate the clinical efficacy and safety of the treatment of vascular cognitive impairment, and to further improve the theoretical basis of the clinical efficacy and safety of FAQ。Method:1. The research way of thinking, with the purpose of "the equal importance of De of, omni-directional commentary" principle, in the attention based on objective facts and the efficacy of, from the aspects of theoretical origin, etiology and pathogenesis, syndrome differentiation, prescription medication, clinical curative effect for the starting point, comprehensively and systematically and explore the teacher’s academic expertise and academic thoughts。 In the process of learning, analysis and summary of the teacher’s academic thought, the author puts forward his own opinions and views, and puts forward the essence of the teacher’s academic thoughts。2. The selected 76 cases of deficiency of liver and kidney and the type of phlegm and blood stasis in vascular cognitive impairment patients, according to the number of tables were randomly divided into observation group and control group, each of 38 cases, observation group were treated with donepezil 5 mg, daily 1 plus Yuzhuoqing granule Pack 1,2 times a day; the control group were treated with donepezil Qi 5 mg, once a day, with a course of 8 weeks. The clinical efficacy of the two groups was compared with the simple mental state scale (MMSE), social function activity questionnaire (FAQ), daily living function (ADL), clinical dementia rating scale (CDR) in 4 weeks and 8 weeks。Result:1. Academic experience:the academic thoughts of Professor of Fujian Province 362000 is source in Neijing "hepatorenal homologous" and "Jin of homologous blood" thought, and specialized theory is permeated with Shanghanlun, synopsis of prescriptions of the golden chamber, general treatise, the treatment of epidemic febrile disease differentiation "," medical Zhong Shen Xi Lu "Chinese classics" homologous phlegm and blood stasis, comorbidity, and Tongzhi "concept gist. In nearly 40 years of clinical practice gradually formed its own unique experience in the diagnosis and treatment. He brilliantly presented "deficiency of liver and kidney, blockage of phlegm and blood stasis meridians is because of cardiovascular and cerebrovascular diseases causing" and "removing blood stasis and tonifying liver and kidney is the treatment, the main treatment of cardiovascular and cerebrovascular diseases is the point. Using this theory to guide the clinical treatment of various difficult and severe diseases in Department of internal medicine, especially cardiovascular disease curative effect is significant。2. Clinical research:(1) in the treatment of 4 weeks and 8 weeks of MMSE score and treatment before, group were observed by 18.81+4.23 increased to 19.92+784 and 21.82+ 3.11, the difference is statistically significant (P< 0.05, P< 0.01); control group respectively by 19.03.93+increased to 19.71+3.12 and 20.45+3.32, the difference was statistically significant (P< 0.05), and the difference between the two groups has statistical significance (P < 0.05, P< 0.01). Treatment for 4 weeks and 8 weeks of FAQ score and treatment of comparison and observation group respectively by 25.22+372 reduced to 22.81+2.23 and 14.96+5.11, the difference is statistically significant (P< 0.05, P< 0.01); control group respectively by 24.92+4.14 reduced to 2.31+3.41 and 16.73+5.20, the difference was statistically significant (P< 0.05). The difference between the two groups has statistical significance (P< 0.05, P< 0.01). The treatment of 4 weeks and 8 weeks of ADL score and treatment, the observation group were from 64.0+11.21 reduced to 48.61+882 and 29.98+ 10.11. The difference is statistically significant (P< 0.01, P< 0.001); control group respectively from 65.44+983 reduced to 51.52+791 and 34.31+874, the difference had statistical significance (P< 0.01). The difference between the two groups has statistical significance (P< 0.05, P< 0.01). The treatment of 4 weeks and 8 weeks of CDR score and treatment, the observation group respectively by 1.68+0.32 reduced to 145+0.24 and 1.29+ 0.15, the difference is statistically significant (P< 0.01, P< 0.001); control group respectively by 1.61+0.30 reduced to 1.55+0.51 and 1.42+0.23 and the difference is statistically significant (P< 0.01); the difference between the two groups has statistical significance (P< 0.05, P< 0.01). To observe the clinical curative effect of the treatment group the total effective rate was 78.9%, better than that of the control group was 63.2%, comparison between groups, the difference was statistically significant (P<0.05); symptom scores for 4 weeks and 8 weeks, the observation group respectively before treatment by 26.42+5.28 reduced to 20.92+2.24 and 10.23+3.71, there were significant differences (P<0.05, P<0.005); the control group before treatment by 25.95+4.99 reduced to 22.78+4.51 and 20.12+3.42, there were significant differences (P<0.05); comparison between groups, the differences were significant (P<0.01, P<0.001); the clinical curative effect of observation group after treatment on the total the efficiency is 78.9%, better than 63.2% in the control group, comparison between groups, the difference was statistically significant (P<0.05). The two groups before and after treatment the WBC, RBC, HGB, PLT is no statistical significance (P> 0.05). Before and after treatment in two groups of liver function (alt, AST), renal function (BUN, SCR) no statistically significant (P> 0.05).Conclusion1. Yuzhuoqing granule combined with superior comprehensive efficacy of donepezil in the treatment of donepezil alone。2. Blood stasis turbid clearing granule combined with donepezil improved in patients with vascular cognitive impairment of cognitive function, activities of daily living, social activity ability is better than the single treatment with donepezil。3. with the increase of period of treatment, the curative effect of Yuzhuoqing granule combined with donepezil is more significant。4. stasis turbid granules had no obvious toxic side effect。... |
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