The Clinical Observation Of Tian Wang Bu Xin Dan Jia Jian Fang Treatment On The Critical Illness Patients With Heart Failure In Sepsis (Qi And Yin Deficiency Syndrome)

Objective:To observe the effects of Tian Wang Bu Xin Dan Jia Jian Fang treatment on the critical illness patients with heart failure in sepsis (Qi and Yin deficiency syndrome) and explore the acting mechanism of Tian Wang Bu Xin Dan Jia Jian Fang,which provides evidence theory and practice for guiding to promote and use Tian Wang Bu Xin Dan Jia Jian Fang.Methods:By using randomized controlled exploratory research methods, we included 40 patients with heart failure in sepsis (Qi and Yin deficiency syndrome) in ICU, which were randomly assigned to control group and treatment group (both were 20 cases). Control group accepted conventional western medicine treatment, and while the treatment group was given Tian Wang Bu Xin Dan Jia Jian Fang on the basis of conventional western medicine treatment.A daily dose, two bags of each dose (thick herbs,100 ml/bag), a bag in the morning and night. The period of treatment is 10 days. Before and after treatment, we evaluated the symptoms of TCM syndrome score, APACHE Ⅱ scores and monitoried high sensitivity C-Reactive protein (HSCRP)and the white blood cell count(WBC), for evaluating improvements in sepsis; we monitoried cardiac troponin T (cTnT), brain natriuretic peptide (BNP), non-invasive cardiac function tests relevant results (CO), echocardiographic relevant results(LVEF%,E/A) for evaluating improvements in heart failure; Finally, we evaluated the clinical curative effect of Tian Wang Bu Xin Dan Jia Jian Fang treatment on the critical illness patients with heart failure in sepsis (Qi and Yin deficiency syndrome),by analyzing the resulting data statistically.Results:1. In the aspect of TCM symptoms symptoms:(1) Comparison in the group: Compared before treatment with after treatment in the treatment group,and the control group similarly.In the two groups,after treatment syndrome improved, such as heart palpitations, shortness of breath, fatigue, shortness of breath, tongue and pulse syndrome, espectively.Difference is statistically significant (fd<O.05, Pz<0.05); (2) Comparison between groups:the total efficiency of the treatment group (77.78%) than the control group (58.82%), P=0.0382;2. In the aspect of heart failure condition changes:(1) Comparison in the group: Compared before treatment with after treatment in the treatment group,and the control group similarly. Eespectively,in the two groups,after treatment cardiac troponinT (cTnT) and BNP are reduced, CO, LVEF% and E/A were increased, the difference is statistically significant;(2) Comparison between groups:After treatment, the treatment group was more obvious than control group in terms of decreasing in cardiac troponinT(cTnT) and BNP and increasing in Co、LVEF%、E/A, the difference is statistically significant;3. In the aspect of sepsis condition changes:(1) Comparison in the group: Compared before treatment with after treatment in the treatment group,and the control group similarly. Eespectively,in the two groups,after treatment high sensitivity C-Reactive protein (HSCRP)and the white blood cell count(WBC) are reduced, the difference is statistically significant;(2) Comparison between groups:The treatment group was more obvious than control group in terms of decreasing in high sensitivity C-Reactive protein (HSCRP)and the white blood cell count(WBC),the difference is statistically significant (P<0.05)4. In the aspect of disease severity and prognosis:(1) Comparison in the group: Compared before treatment with after treatment in the treatment group,and the control group similarly. Eespectively,in the two groups,APACHE Ⅱ score is reduced, the difference is statistically significant;(2) Comparison between groups:The treatment group was more obvious than control group in terms of decreasing in APACHE Ⅱ score,the difference is statistically significant (P<0.05);Conclusion:The curative effect of Tian Wang Bu Xin Dan Jia Jian Fang combined with western medicine treatment on the critical illness patients with heart failure in sepsis (Qi and Yin deficiency syndrome) was better than western medicine treatment simply.