The Clinical Observation Of Selective Head Mild Hypothermia Treatment Induced Within 6-10 Hours After Birth In Newborns With Hypoxic-ischemic Encephalopathy

Objective The clinical observation of selective head mild hypothermia treatment induced within 6-10 Hours after Birth in newborns with Hypoxic-ischemic encephalopathy. Methods thirty-three term infants with moderate-to-severe HIE were randomly assigned to either selective head mild hypothermia treatment(n = 17) or conventional treatment(n =16).Family members were told the state of illness and agreed to implement the treatment. Hypothermia was induced within 6-10 hours after birth, decreasing nasopharyngeal temperature to(34± 0.2)C for 72 hours, followed by slow rewarming to 36.5°C. Neurodevelopmental outcome was assessed at 3and6 months old in the Chinese standardization BENAN Scale which included mental development index(MDI) and motor development index( PDI).Comparison of the two groups of children mortality and severe neurodevelopmental disability rate,and the incidence of adverse reactions. Results The BENAN was used to measure MDI and PDI at 3 and 6 months,l ow temperature group were significantly higher than the control group. Death or moderate-to-severe disability occurred in 5 of 16 infants(31.25%) in the control group and in 3of 17infants(17.65%) in the hypothermia group(P = 0.05) at 6 months. The rate of adverse events was similar in the hypother-mia and control group during the first 4 postnatal days,No severe hypothermia-related adverse events were observed. Conclusion selective head mild hypothermia treatment induced within6-10 Hours after Birth in newborns with Hypoxic-ischemic encephalopathy is safy and effective and have better clinical curative effect to prevent or reduce the neurological sequelaea,improve the quality of survival...