Study On Relationship Between Premature Infant With Pneumonia And STREM-1, IFN-γ & IL-13

Objectives:To Investigate the function and clinical value of the serum level of soluble triggering receptor expressed by myeloid cells (sTREM-1)^ Interferon-y (IFN-y) and Interleukin-13 (IL-13) of premature infant with pneumonia.Methods:Selected 53 cases of hospitalized premature infants with pneumonia from January 2014 to December 2014, including severe group (A) 22 cases and mid group (B) 31 cases, and selected 21 cases of hospitalized premature infants which were admitted just because of premature birth without discharged history and special medical record as control group (C). sTREM-1, IFN-y and IL-13 in A and B were tested by enzyme-linked immunosorbent assay (ELISA), before and after treatment. The level of C group were tested, as the cases were recruited.Results:1.Before treatment, the level of sTREM-1 and IL-13 of A and B was significantly higher than C (P<0.05), and the level of sTREM-1 and IL-13 of A was higher than B (P<0.05). After treatment, the level of sTREM-1 and IL-13 decreased gradually, which had a significant statistic difference (P<0.05).2.Before treatment, the level of IFN-y in A and B was significantly higher than C (P<0.05), but there was no significant statistic difference between A and B(P>0.05). After treatment, the level of IFN-y decreased gradually, which had a significant statistic difference (P<0.05).3.Before treatment, the level of IFN-y/IL-13 of A and B was significantly higher than C (P<0.05), and the level of IFN-y/IL-13 in A was higher than B (P<0.05).Conclusions:1.sTREM-1, IL-13 and IFN-y all participated in the progression of premature infant with pneumonia. The level of IFN-y/IL-13 of premature pneumonia was lower than control group, which indicated that the premature infant with pneumonia had the unbalanced ratio of inflammatory factors which were secreted by Thl/Th2 cell.2.The level of sTREM-1 and IL-13 had a relationship with the severity of pneumonia, they were helpful for us to evaluate the patient’s condition.3.After treatment, the level of sTREM-1, IL-13 and IFN-y decreased gradually, which indicated that the changes of them were useful for us to evaluate the therapeutic effect.