| Background:Colorectal Polyps (CRP) are an abnormal growth of mucosal tissue protruding into the colorectal cavity. The large numbers of CRP develop slowly and seldom cause symptoms until they reach a definite size. Inflammatory and Hyperplasic polyps do not carry a risk of developing into colorectal cancer (CRC), but colorectal adenomas considered pre-cancerous. The prevalence of colorectal polyps increases with the increasing of living standard. The prevalence of CRP is more common in development places than rural districts. The incidence of colorectal polyps reported to be associated with a variety of inflammatory factors, serum lipids profile abnormalities and high levels of fasting blood sugar. The previous studies have not illustrated the correlation between the levels of serum Uric Acid (UA) and the levels of serum Triglyceride (TG), Total Cholesterol (TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Fasting Blood Sugar (FBS), and Carcinoembryonic Antigen (CEA) in the patients with colorectal polyps. Therefore, this thesis aims to evaluate the association between those parameters and serum UA levels in the patients with colorectal polyps.Purpose of the thesis:The purpose of the thesis is to identify the association between serum TG, TC, LDL, HDL, FBS, and UA and the incidence of colorectal polyps. Furthermore, this thesis aims to explore the correlation between those parameters and the age and gender of the patients, and with size, location, numbers, and histological patterns of the colorectal polyps. The ultimate purpose of the thesis is to assess the correlation between serum (UA) and serum (TG), (TC), (HDL), (LDL), (FBS) and (CEA) in the patients with colorectal polyps.Subjects and Methods:279 patients with CRP and 194 healthy individuals as normal controls were involved to this research. Blood serum biomarkers were measured in each participant. Size and number of colorectal polyps were estimated under guidance of colonoscopy. Colorectal polyps’tissues were obtained during colonoscopy screening or during polypectomy procedures. Blood biomarkers reports and polyps histological reports were obtain from the department of laboratory and department of pathology of Northern Jiangsu people’s Hospital, respectively. All the data were statistically analyzed to assess the correlation between the variables in the patients and controls using SPSS 19. P<0.05 consider significant.Results:Research results revealed that the percentages of patients with elevated levels of UA, TG, TC, LD, and FBS were significantly higher in colorectal patients group than those in normal individuals group (p<0.05). By contrast, the ratio of patients with decreased serum HDL levels was significantly higher in colorectal patients group compared to healthy controls (P<0.05). CEA levels were higher in patients compared to controls, but the differences were not significant. TG, TC, LDL levels were positively correlated with serum UA levels in patients with RCP, r =0.31,0.18,0.2 respectively, while UA levels were negatively correlated with HDL levels in the same patients group, r=-0.21. However, our finding did not detect a significant correlation between UA levels and FBS and CEA levels in this patient group, (p=0.72,0.5), respectively. Serum UA levels were higher in male gender patients than female gender patients (P<0.05). Moreover, the ratio of patients with high levels of serum UA were higher in adenomatous polyps group than those in hyperplasic or inflammatory polyps group (p<0.05).Conclusion:Increased serum TG, TC, LDL, FBS and UA levels and decreased serum HDL levels were correlated with increase the incidence of CRP. The interaction between serum UA and TG, TC, HDL, and LDL may increase the risk of the incidence of colorectal polyps. Degree of the dysplasia of colorectal polyps’tissues is associated with increased serum UA levels. Therefore, study the potential risk for those markers may represent promising indicators in evaluation and protection of this lesion and its progression. |
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