The Relationship Between Sleep Duration And The Risk Of Cerebral Infarction

Objective:Previous reports have shown an association between sleep duration and cerebral infarction. Unusual sleep duration may be a risk factor or detector of stroke. To explore the relationship between sleep duration and cerebral infarction, we performed a case-control study involved 319 ischemic stroke patients and 300 cerebrovascular disease free matched group.Methods:A case-control study involved 319 cerebral infarction patients admitted by the First Affiliated Hospital of Kunming Medical University, July 2014 to December 2015. Another 300 adults free from cerebrovascular diseases who had received physical examination or been examined in outpatient apartment in the same hospital at the same period, were served as control group. All the subjects were interviewed with an unified questionnaire to identify sleep duration and related stroke risk factors. T-test, Chi-square test and multivariate logistic regression analysis were performed to analyze the collected data.Results:Prolonged sleep was significantly associated with cerebral infarction.After adjustment for potential confounding factors including age, sex, body mass index, hypertension, diabetes mellitus, coronary artery disease, hyperlipemia, smoking, alcohol intake and exercise habits, data from the multivariate logistic regression analysis showed that the risk of cerebral infarction was greater in people who slept more than 8 hours per day than those who slept between 7 to 8 hours per day, with an odds ratio as 2.81 (95%C1:1.74～7.54). Through the subgroup analysis, the increased risk of cerebral infarction with long durations of sleep was seen among both women and men with the odds ratio as 4.79 (95%CI:2.03～11.27) and 2.38 (95%CI:1.28～4.41) respectively. The association was seen among subjects with a history of hypertension(6.33,2.87～13.99), but not in those without hypertension (1.90,0.89～4.02). The degree of association was greater in diabetes mellitus patients (3.71,1.24～11.08)than those without diabetes mellitus(2.77,1.55～4.94), while there is a stronger association among those without hyperlipemia (5.05,1.71～14.96) than hyperlipemia patients (2.74,1.34～5.58).Conclusion:Long sleep duration is associated with increased risk of cerebral infarction, and this association is stronger among women than among men. The degree of this association was greater in hypertension and diabetes mellitus patients than in those with no diagnose, while there was a stronger association in those without hyperlipemia than in hyperlipemia patients.