| Objective:Pulmonary interstitial fibrosis and emphysema syndrome is a kind of lung disease which has been put forward in recent years, has not yet been widely recognized by experts and scholars of various countries. To analyze the clinical data of patients with pulmonary interstitial fibrosis and emphysema syndrome, to popularize and improve the clinicians’cognition of CPFE syndrome, and hope to provide clinical references for the final establishment of the disease.Methods:We designed two different groups of hospitalized patients since January 2013 to March 2016 in the Affiliated Hospital of Yanbian University:case of CPFE, case of IPF. To retrospectively analyse the clinical data of two groups.Results:1.21 cases of CPFE were enrolled in this study,15 cases were male,6 cases were females; 11 cases of the Korean nationality,1 case of Manchu,9 cases of the Han nationality; the average age was about 71.38±10.14 years old. There were 16 smokers in CPFE group (15 males and 1 female), the history of smoking were 10-50 years, the average smoking index were 466±455. There were nospecific clinical manifestations, the main symptomswere cough, expectoration and different degrees of difficulty in breathing,13 cases could be heard Velcro sound in the lower part of the doublelungs,6 cases had clubbing finger (toe).21 patients were diagnosed as ILD at the first time.3 cases were diagnosed with squamous cell carcinoma of the lung.10 cases were diagnosed with pulmonary arterial hypertension, the average pulmonary arterial pressure was 44.25±11.61mmHg. Blood gas analysis:the average of PaO2 was55.95±17.22mmHg, mean PaCO2was34.81±7.62mmHg. Lung function index:5 cases of obstructive ventilatory dysfunction,6 cases ofrestrictive ventilatory disorder, 10 cases of mixed ventilation dysfunction,15 cases of diffusion dysfunction,3 cases were not completed with diffusion function detection. FEV1%pre 89.14±27.98%, FVC%pre 84.71±27.41%, FEV1/FVC 83.28±7.72%, RV/TLC 47.52±14.49%, TLC%pre 87.28±39.63%. DLco%pre 47.42±26.74%.21 cases showed that lung upper lobe were varying degrees and different types of emphysema, and lower lobe of lung were interstitial fibrosis on HRCT. Emphysema types included:paraseptal type (12cases,57%), centrilbular (9cases,43%), pulmonary bulla fusion(12cases, 57%). Pulmonary fibrosis types included:there 16 cases showed reticulation (76%). 4 caseshoneycombing (19%),5cases in ground glass opacity (24%).2. Comparedthe characteristics of CPFE and IPF group, the average pulmonary artery pressure:t=2.392, P= 0.021; lung function index:FEV1/FVC, t=2.472, P= 0.017; TLC%pre, t=2.574, P= 0.013; RV/TLC%, t=2.917, P= 0.005. Think there were significant differences in the above indexes.Conclusion:1. HRCT combined with pulmonary function test is an important diagnostic method for CPFE syndrome.2. CPFE syndrome is more likely to be combined with pulmonary hypertension than CPFE. |
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