Comparison Of Different Doses Of Dexmedetomidine For Sedation And Hemodynamic Effects In Mechanically Ventilated Patients In ICU

OBJECTIVE:To observe the sedation efficacy and safety by different doses of dexmedetomidine used in ICU and find out the reasonable dosing regimen for clinical application.METHODS:70 patients with endotracheal intubation in ICU of Chang Shu First People’s Hospital were randomly divided into two groups. Dexmedetomidine was given in Group A with maintenance dose of 1.0ug/kg/h from the very beginning, while in Group B with the maintenance dose of 0.6ug/kg/h. No loading dose was given in both two groups. The sedation efficiency, the variation of blood pressure and heart rate in different specified point-in-time, duration of mechanical ventilation, fentanyl dosage, incidence of delirium and the time in ICU were compared between the two groups.RESULTS:The time to get to the target RASS of the two groups had no statistical difference(P>0.05);The sedation effect in different specified point-in-time between two groups had no statistical difference(P>0.05);There is no difference on the time of shallow sedation between the two groups during the first 72 hours(P>0.05); while the time of deep sedation between the two groups has statistical difference(P<0.01);Compared to Group B, Group A had more significant changes on hemodynamics(P<0.05);The mechanical ventilation time between two groups had no statistical difference(P>0.05);Group A need more dosage of norepinephrine(P<0.05);Group B need more dosage of fentanyl(P<0.01);The incidence rate of delirium between two groups had no statistical difference(P>0.05).The length of stay in ICU between two groups had no statistical difference(P>0.05).CONCLUSION:Dexmedetomidine used in ICU with the maintenance dose of 0.6ug/kg/h has good sedative effect, hemodynamic stability, lower norepinephrine dosage, which is appropriate dosage compared to the dose of 1.0ug/kg/h.