A Clinical Study Of Association Between Serum Uric Acid Levels And Type 2 Diabetic Kidney Disease

Objective: To assess the relationships of serum uric acid(SUA) level with renal damage and cardiovascular complications in type 2 diabetic kidney disease.Methods: The cross-sectional study was performed with a sample of 710 patients with type 2 diabetic kidney disease. There were 435 patients with complete cardiac ultrasound and carotid ultrasound data. Subjects were classified according to CKD stage, SUA quartiles, hyperuricemia or not in men and women. One-way ANOVA, nonparametric test or χ2 test were applied to the comparison between each group. The spearman analysis and logistic regression analysis were used to analyze the relationship of SUA and renal function, left ventricular hypertrophy and carotid atherosclerosis in type 2 diabetic kidney disease.Results: 1. The T2 DKD patients with hyperuricemia accounted for 40.25% of total number.2. Spearman analysis shown that SUA was positively associated with UAER、UACR、TG、CRP、LVMI and negatively associated with HbA1c、HDL、eGFR. There was no significant association with SUA and CIMT in the T2 DKD patients(P<0.05).3. The stepwise adjusted logistic analysis shown that there were significantly increased risk of eGFR<60ml/min·1.73m2 or LVH in quartiles with higher SUA, after adjusted possible confounding factors including UACR、SBP、DBP、HbA1c、TC、TG、HDL、LDL、gender、smoking、alcohol、DD and AHA(P<0.05).Conclusions: SUA was associated with an increased risk of renal damage or left ventricular hypertrophy in patients with T2 DKD, and we should put emphasis on SUA in clinical works.