| Dysmenorrhea is a common disease that seriously affects women’s life and work, the incidence rate is as high as 30%-50%, and it is easy to recur. Although after a long period of research and exploration, in the western medicine, the treatment of this disease is still not easy and effective way. Traditional Chinese medicine and Western medicine are rich in treatment of dysmenorrhea, however, Chinese medicine treatment of dysmenorrhea medicine side effect is small, the effect is obvious, easy to accept Blood stasis type primary dysmenorrhea in the cold area, the characteristics of acute, obvious pain, severe pain, cold and even more severe pain. Patients with abdominal cramps, need to rest in bed, seriously affecting the quality of life of patients. Therefore, to explore a simple, effective, and inexpensive treatment method has been the direction and objective of clinical researchers.In this study, two parts of research by animal experiments and clinical trials confirm the Shenque point moxibustion treatment of dysmenorrhea (the type of cold coagulation and blood stasis is effective and safety, for the clinical treatment of the disease develops new ideas and methods.Purpose:With the syndrome of cold coagulation and blood stasis dysmenorrhea of dysmenorrhea model rats as the object of study of Shenque point moxibustion treatment effect and mechanism of dysmenorrhea (the type of cold coagulation and blood stasis. And collection of clinical type of cold coagulation and blood stasis dysmenorrhea patients to study to validate Shenque point moxibustion treatment of the clinical effect of dysmenorrhea (the type of cold coagulation and blood stasis and Western medicine ibuprofen and compared to verify the Shenque point moxibustion treatment dysmenorrhea (the type of cold coagulation and blood stasis is effective and safe.method:1. Animal experiment:40 SD rats were randomly divided into normal control group, model control group, western medicine group and moxibustion group,10 rats in each group. Except the normal control group, other rats to 0-1 DEG C water bath repeated stimulation method and combined with estradiol valerate gavage, oxytocin intraperitoneal injection to promote contraction of rat uterine create syndrome of cold coagulation and blood stasis dysmenorrhea rat model. After modeling, the model of Western medicine group was treated with ibuprofen, model group moxibustion Shenque point moxibustion treatment, at the end of the experiment, the observed in four groups of rats of oxytocic hormone induced writhing reaction times, PGE2 was detected in the rat endometrium PGF2a content, , the PGF2a/PGE2 value was calculated, and the content of -EP in peripheral blood of rats was detected.2. Clinical trials:clinical data collected in 30 cases diagnosed as the cold blood stasis type primary dysmenorrhea patients, randomly divided into western medicine group and moxibustion group. Western medicine group were treated with ibuprofen, moxibustion Shenque point moxibustion treatment. Three courses of treatment before and, respectively, after evaluation each VAS pain scores, Cox dysmenorrhea symptoms score and efficacy and in between the two groups, within each group were compared.result:animal experiments:(1)torsional response:Model control group, model western medicine group, model moxibustion group compared with the normal control group were statistically significant (P<0.05), which showed that after modeling, regardless of whether or not to dispose of, oxytocin induced pain in rats was significantly higher than normal. Model of Western medicine group and moxibustion group were compared with the model control group were statistically significant differences between the model group and the model group, the results suggested that there was no statistical difference between the two groups.(2) PGE2, PGF2a content, PGF2a/PGE2 value in the endometrium of rat model:Compared to each group, there was no significant difference in the content of PGE2 in the uterus of the dysmenorrhea model of blood stasis rats. Compared with the normal control group, the content of PGF2a in the endometrium of model control group was increased (P<0.05);Model of Western medicine group, model moxibustion group compared with the model control group, the PGF2a content of the uterus in the uterus of rats decreased significantly. Model of Western medicine group and model moxibustion group, the PGF2a content of the uterus in the uterus of the model group was not statistically different. Compared with the normal control group, the ratio of PGF2a/PGE2 in the uterine tissues of the model control group was increased (P<0.05), Model moxibustion group, model western medicine control group significantly decreased the ratio of PGF2a/PGE2 content in uterine tissue, compared with the model control group with significant difference (P<0.05)(3) The content of -EP in peripheral blood of model rats:In model control group, the ratio of peripheral blood beta -EP in the model group was not significantly different than that in the normal control group, Model moxibustion group, model western medicine control group, the ratio of peripheral blood beta -EP content of model group was significantly higher than that of model control group (P<0.05),Model western medicine group compared with the model moxibustion group, there was no difference in the content of beta -EP in peripheral blood.2. clinical experiment:(1) VAS pain score:The two groups of patients before treatment, after treatment, the total score of VAS pain scores were not statistically significant differences. Western medicine group and moxibustion group before and after treatment VAS pain scores were statistically significant.(2) COX dysmenorrhea symptom score:两There was no significant difference between the two groups before treatment and after treatment with COX dysmenorrhea symptom score scale,, The western medicine group and moxibustion group two groups of patients before and after treatment group were statistically significant.(3) Comparison of two therapeutic methods:There was no significant difference in the total effective rate between the two groups.conclusion1. Moxibustion on Shenque point and ibuprofen can significantly reduce the type of cold coagulation and blood stasis rat model by oxytocin induced writhing response times and frequency of occurrence, suggesting that moxibustion on Shenque point and ibuprofen on dysmenorrhea has obvious analgesic effect, and both are quite effective.2. Moxibustion on Shenque point and ibuprofen can lower cold coagulation and blood stasis dysmenorrhea rat model of uterine PGF2a content, in the rat model of uterine PGE2 had no effect so as to make the model rat uterine PGF2a and PGE2 values decreased. Prompt Shenque point moxibustion and Western medicine ibuprofen may adjust dysmenorrheal model rats with abnormal uterine PGF2a and PGE2 ratio, inhibit uterine smooth muscle spasm, analgesic effect, and both are quite effective.3. Moxibustion on Shenque point and ibuprofen can improve cold coagulation and blood stasis dysmenorrhea model rats in peripheral blood levels of beta endorphine. Moxibustion on Shenque point and ibuprofen tips through increase in blood and other tissues of the b-EP content, to adjust threshold of pain and analgesia, and both are quite effective.4. After three courses of treatment, moxibustion on Shenque point and ibuprofen can reduce of congealing cold and blood stasis dysmenorrhea VAS pain scores, suggesting the two treatments were decreased in patients with the degree of abdominal pain and both are quite effective.5. Moxibustion on Shenque point and ibuprofen can reduce cold coagulation and blood stasis dysmenorrhea patients Cox dysmenorrhea symptom score and tips after three courses of treatment, two groups of patients with dysmenorrhea symptoms relieved or disappeared and the treatment effect of two methods. 6. After three courses of treatment, and ibuprofen treated type of cold coagulation and blood stasis dysmenorrhea patients, the effective rate reached 73.33% and moxibustion Shenque point method, the effective rate reached 80%, but the two are not statistically significant, indicating that the two treatment methods have similar effects.7. Safety analysis, although in the two treatments were not found in security incidents, but controllable moxibustion related security incidents, can prevent and ibuprofen are still in some of the patients, taboo and other drug interactions caused harm. So moxibustion advantage obvious. |
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