Analysis For The Potential Risk Factors Of Chronic Pain Following Breast Cancer Surgery

Objective:To explore the domestic status quo and the related factors of chronic post-surgical pain after breast cancer by performing the epidemiological investigations.Methods:A total of 322 women with primary breast cancer were investigated. A 9-month follow-up survey after surgery was conducted and 10 related factors of chronic pain were recorded 3 months and 9 months after surgery, including age, body mass index (BMI), preoperative anxiety depression, preoperative pain, preoperative chemotherapy, breast surgery way, axillary surgery way, acute postoperative pain, postoperative chemotherapy,and postoperative radiotherapy. The association of chronic post-surgical pain after breast cancer with each variable was evaluated by logistic regression analysis.Results:The incidence of chronic pain 3 months and 9 months after surgery was 61.0% and 56.2%, respectively. The univariate correlation analysis showed that the chronic pain after 3 months associated with three factors:age, axillary surgery way, acute postoperative pain (P<0.05), and one more factors after 9 months:preoperative pain syndrome P<0.05). Binary logistic regression analysis showed that younger age, axillary lymph node dissection, moderate to severe acute postoperative pain were significant independent risk factors of chronic pain following breast cancer surgery (P <0.05,OR>1).Conclusion:In 9 months after breast cancer surgery, the incidence of chronic post-surgical pain was high,which is associated with younger age, axillary lymphnode dissection and moderate to severe acute postoperative pain. The reduction of surgery injury, especially the nerve injury, the replacement of sentinel lymph node biopsy to traditional axillary lymph node surgery, the positive intervention of younger patients, the prevention and alleviation of acute postoperative pain may reduce the incidence of chronic post-surgical pain and improve the quality of life of patients.