The Research Of Risk Factors About Pelvic Lymph Node Metastasis In Cervical Cancer And The System Review About The Correlation Between Cervical Cancer And SNP On The P53 Gene

Part Ⅰ The research of risk factors about pelvic lymph node metastasis in cervical cancerBackground:Cervical cancer is one of the women’s common malignant tumor. Cervical cancer is the most common malignant tumor in the reproductive system of gynaecology. The morbidity and mortality of cervical cancer is lower than that in the breast cancer. Lymphatic metastasize and blood metastasize are the two important way of the tumor metastasis. Lymphatic metastasis has correlation with the prognosis of cervical cancer and cervical lymph node metastasis has been the important independent predictor of prognosis about cervical cancer. Establish the preoperative evaluation system of lymph node metastasis in cervical cancer patients is very important. Pelvic lymph node metastasis about cervical cancer has correlation with the prognosis of cervical cancer.It is important to accurately determine the risk factors for pelvic lymph node metastasis in cervical cancer patients. It candetermine the individualized treatment plan for cervical cancer patients and select the reasonable scope of operation. It also can improve the patient survival and quality of life for cervical cancer patients. There is the important clinical significance on all that aspect.Objective:1. To understand the most common sites of pelvic lymph node metastasis on cervical cancer patients.2. To analyze the risk factors of pelvic lymph node metastasis on cervical cancer patients.3. To explore the independent risk factors of pelvic lymph node metastasis in cervical cancer patients.Methods:The retrospectively collect the clinical pathological datum of 337 cervical cancer patients who were underwent surgical treatment. By the way of the case-control study and Logistic regression analysis, explore the risk factors of pelvic lymph node metastasis in patients with cervical cancer.Results:1. The most common sites of pelvic lymph node metastasis in cervical cancer patients is lymph nodes on foramen obturatorium area.2. The risk factors of pelvic lymph node metastasis in cervical cancer patients including age, clinical stage, tumor size, tumor infiltration depth, lymph-vascular space involvement and utero-tissue infiltration.3. The tumor size (OR=4.316, P=0.001), tumor infiltration depth (OR=3.464, P =3.464), lymph-vascular space involvemen (OR=6.167, P<0.001) and tumor utero-tissue infiltration (OR=8.507, P=8.507) are independent risk factors of pelvic lymph node metastasis in cervical cancer patients.Conclusion:The myometrial invasion≥2/3, the size of tumor≥4cm,lymph-vascular space involvement and utero-tissue infiltration positive lymph node metastasis of cervical cancer are easy to occur.Part II The system review about the correlation between cervical cancer and SNP on the p53 geneBackground:So far, the pathogenesis of cervical cancer is not fully clear. The incidence of cervical cancer is a complicated multistep procedure. There are many factor sinvolving heredity, exogenous factors and many other factors in that procedure. In recent years, some researchers focus on the gene polymorphism and the susceptibility on cervical cancer. At present, the correlation between the p53 gene exon-4 codon 72 gene polymorphism and the incidence on Chinese women cervical cancer is not clear. The conclusion is not the samein different regions and different races.Objective:To system evaluate the genetic correlation between p53 gene exon-4 codon 72 G/C single nucleotide polymorphism and cervical cancer in the Chinese women.Methods:All the literatures of case-control research on the correlation between G/C polymorphism of p53 gene exon-4 codon 72and cervical cancer in Chinese women. The related datum should be analyzed in the way of statistics. To system evaluate the genetic correlation between p53 gene exon-4 codon 72 G/C single nucleotide polymorphism and cervical cancer in the Chinese women.Results:Nine studies involving 1116 cervical cancer patients and 771 healthy volunteers were included. The results of meta-analyses showed that the allele G had no increased relative risk compared to the allele C (OR=1.15,95%CI(0.79,1.67)).Conclusion:This meta-analysis doesn’t demonstrate the correlation between p53 gene exon-4 codon 72G/C single nucleotide polymorphism and cervical cancer in Chinese women.