Study Of Relation Between Serum Retinol Binding Protein 4 (RBP4) Level And Type 2 Diabetes Mellitus Patients Complicated With Acute Cerebral Infarction

Background and ObjectiveThe Recent epidemiological survey showed that the estimated prevalence of diabetes among a representative sample of Chinese adults was 11.6%, which means there was up to 113.9 million Chinese adults with diabetes. The macrovascular complications like cardiovascular and cerebrovascular diseases, may cause patients with T2DM disability and death. Acute cerebral infarction (ACI) has been widespread concerned because it is as an extremely important macrovascular complication of diabetes. Serum retinol binding protein 4 (RBP4) is a newly discovered adipokine which can suggest obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and certain components of the metabolic syndrome. Whether RBP4 can be used as a predictor of type 2 diabetes mellitus (T2DM) complicated with acute cerebral infarction (ACI) is rarely reported nowadays. Based on the background above, we try to explore the relation between serum retinol binding protein 4 (RBP4) level and type 2 diabetes mellitus patients complicated with acute cerebral infarction by reviewing these caces.MethodsThe patients who were admitted to the Affiliated Hospital of Yangzhou University from June 2014 to January 2015, were selected as study subjects,30 patients with type 2 diabetes mellitus complicated acute cerebral infarction were included in A group,30 patients with type 2 diabetes mellitus complicated old cerebral infarction were included in B group,30 patients with type 2 diabetes mellitus were included in C group,30 patients with cerebral infarction were included in D group and 30 healthy people were included in control group. The levels of TC, TG, LDL-C, HDL-C, cystatin C, fasting plasma glucose(FPG), HbAlc, RBP4 were compared among groups. The relevant factors for RBP4 levels were analyzed by Spearman correlation analysis. Multiple factor logistic regression was used to analyze the risk factors. P<0.05 was considered statistically significant.ResultsThere were differences in serum levels of SBP, FPG, TG, HDL-C, cystatin C, HbA1c and RBP4 among 5 groups (P< 0.05); The serum RBP4 levels in A group were significantly higher than those in control group, B group, C group and D group. According to result of Spearman correlation analysis, serum levels of TG and cystatin C were positively correlated with RBP4 level(r value was 0.309 and 0.176, respectively; P<0.05); serum levels of HDL-C was negatively correlated with RBP4 level(r value was-0.249; P=0.003). Multiple logistic regression analysis demonstrates that RBP4(OR=1.188, P=0.038) was signficantly associated with type 2 diabetes complicated with acute cerebral infarction (P<0.05) and SBP(OR=1.133, P=0.011) was signficantly associated with type 2 diabetes complicated with old cerebral infarction (P<0.05).ConclusionThe serum RBP4 level increased in type 2 diabetes mellitus patients complicated with acute cerebral infarction, which indicated that RBP4 can be used as a predictor of type 2 diabetes complicated with acute cerebral infarction.